Gut Microbiota Abrogates Anti-α-Gal IgA Response in Lungs and Protects against Experimental Aspergillus Infection in Poultry

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:39Z
Fecha de publicación2020-01-01
ResumenNaturally occurring human antibodies (Abs) of the isotypes IgM and IgG and reactive to the galactose-alpha-1,3-galactose (alpha-Gal) epitope are associated with protection against infectious diseases, caused by pathogens expressing the glycan. Gut microbiota bacteria expressing alpha-Gal regulate the immune response to this glycan in animals lacking endogenous alpha-Gal. Here, we asked whether the production of anti-alpha-Gal Abs in response to microbiota stimulation in birds, confers protection against infection by Aspergillus fumigatus, a major fungal pathogen that expresses alpha-Gal in its surface. We demonstrated that the oral administration of Escherichia coli O86:B7 strain, a bacterium with high alpha-Gal content, reduces the occurrence of granulomas in lungs and protects turkeys from developing acute aspergillosis. Surprisingly, the protective effect of E. coli O86:B7 was not associated with an increase in circulating anti-alpha-Gal IgY levels, but with a striking reduction of anti-alpha-Gal IgA in the lungs of infected turkeys. Subcutaneous immunization against alpha-Gal did not induce a significant reduction of lung anti-alpha-Gal IgA and failed to protect against an infectious challenge with A. fumigatus. Oral administration of E. coli O86:B7 was not associated with the upregulation of lung cytokines upon A. fumigatus infection. We concluded that the oral administration of bacteria expressing high levels of alpha-Gal decreases the levels of lung anti-alpha-Gal IgA, which are mediators of inflammation and lung damage during acute aspergillosis.es_ES
Doihttps://doi.org/10.3390/vaccines8020285es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5472
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónVaccineses_ES
URL relacionadohttps://doi.org/10.3390/vaccines8020285es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteVaccines
Palabra clavealpha-Gales_ES
Palabra clavemicrobiotaes_ES
Palabra claveaspergillosises_ES
Palabra claveAspergillus fumigatuses_ES
Palabra clavegranulomases_ES
Palabra clavecross-protective immunityes_ES
TítuloGut Microbiota Abrogates Anti-α-Gal IgA Response in Lungs and Protects against Experimental Aspergillus Infection in Poultryes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMateos-Hernandez, Lourdes
AutorRisco-Castillo, Veronica
AutorTorres-Maravilla, Edgar
AutorBermudez-Humaran, Luis G.
AutorAlberdi, Pilar
AutorHodzic, Adnan
AutorHernandez-Jarguin, Angelica
AutorRakotobe, Sabine
AutorGalon, Clemence
AutorDevillers, Elodie
Autorde la Fuente, Jose
AutorGuillot, Jacques
AutorCabezas-Cruz, Alejandro
AutorMateos-Hernandez, Lourdeses_ES
AutorRisco-Castillo, Veronicaes_ES
AutorTorres-Maravilla, Edgares_ES
AutorBermudez-Humaran, Luis G.es_ES
AutorAlberdi, Pilares_ES
AutorHodzic, Adnanes_ES
AutorHernandez-Jarguin, Angelicaes_ES
AutorRakotobe, Sabinees_ES
AutorGalon, Clemencees_ES
AutorDevillers, Elodiees_ES
Autorde la Fuente, Josees_ES
AutorGuillot, Jacqueses_ES
AutorCabezas-Cruz, Alejandroes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
URL relacionadahttps://doi.org/10.3390/vaccines8020285
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen8es_ES

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