Effect of Insulin Resistance on Abdominal Obesity, Liver Fat Infiltration, and Body Mass Index in Youngsters

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:11Z
Fecha de publicación2023-09-01
ResumenAim. Evaluate insulin resistance (IR) as a mediator of the effect of body fat distribution on liver fat infiltration and stiffness (LSt) in young adults using structural equation modeling (SEM).Methods. We invited 500 first year students from two universities and evaluated their family history to determine the risk for cardiometabolic disease. Of these, 174 students (age 19 +/- 1 years) were assessed for total body fat percentage (BF\%), LSt, fat infiltration (Coefficient attenuated parameter CAP), and serum biochemical analysis. We performed a mediation analysis using two different structural equation models to determine the relationship be-tween BMI, BF\%, abdominal obesity (AO), IR, LSt, and fat infiltration using standardized beta coefficients. The symbol ``-> `` means ``explains/causes{''}.Results. Model\#1 supported that mediation analysis and had a better fit than the direct effect. AO-> IR (b = 0.62, p = 0.005), AO-> CAP (b = 0.63, p < 0.001), and CAP-> IR (b = 0.23, p = 0.007), with negligible effect of BMI on CAP and IR. Model\#2 showed direct effect of BMI on LSt was a better fit than mediation. BMI-> LSt (b = 0.17, p = 0.05) but no effect AO-> LSt. Interestingly, LSt-> IR (b = 0.18, p = 0.001), but bi-directional IR-> LSt (b = 0.23, p = 0.001).Conclusions. AO and BMI in young adults have differential phenotypic effects on liver CAP and LSt. Visceral fat had a direct effect on IR and CAP. Meanwhile, BMI was associated with LSt. Our findings shed light on the complex interplay of factors influencing liver stiffness, particularly in young individuals. Further research is needed to elucidate the precise mechanisms underlying these associations and their implications for liver health.es_ES
Doihttps://doi.org/10.1016/j.arcmed.2023.102873es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2841
Idiomaenes_ES
EditorialElsevier BVes_ES
RelaciónArchives of Medical Researches_ES
URL relacionadohttps://doi.org/10.1016/j.arcmed.2023.102873es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteArchives of Medical Research
Palabra claveInsulin resistancees_ES
Palabra claveBody mass indexes_ES
Palabra claveMediationes_ES
Palabra claveInternal medicinees_ES
Palabra claveEndocrinologyes_ES
Palabra claveObesityes_ES
Palabra claveMedicinees_ES
ClasificaciónLiver Disease Diagnosis and Treatmentes_ES
TítuloEffect of Insulin Resistance on Abdominal Obesity, Liver Fat Infiltration, and Body Mass Index in Youngsterses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcía-Oropesa, Esperanza M.
AutorPerales-Torres, Adriana L.
AutorMartínez-López, Yoscelina Estrella
AutorMunguía-Cisneros, Claudia X.
AutorNava‐González, Edna J.
AutorPerez-Navarro, L. M.
AutorRosas‐Díaz, Marisol
AutorBaltazar, Neyla
AutorArroyo-Valerio, América
AutorDíaz-Badillo, Álvaro
AutorGarcía-Oropesa, Esperanza M.es_ES
AutorPerales-Torres, Adriana L.es_ES
AutorCastillo-Ruíz, Octelina
AutorMartínez-López, Yoscelina Estrellaes_ES
AutorMunguía-Cisneros, Claudia X.es_ES
AutorHernández-Ruiz, Joselín
AutorNava‐González, Edna J.es_ES
AutorPerez-Navarro, L. M.es_ES
AutorMummidi, Srinivas
AutorRosas‐Díaz, Marisoles_ES
AutorBaltazar, Neylaes_ES
AutorRamírez-Quintanilla, Laura Y.
AutorArroyo-Valerio, Américaes_ES
AutorDíaz-Badillo, Álvaroes_ES
AutorBustamante, Alejandra
AutorCastillo-Ruíz, Octelinaes_ES
AutorHernández-Ruiz, Joselínes_ES
AutorRamírez‐Pfeiffer, Carlos
AutorMummidi, Srinivases_ES
AutorRamírez-Quintanilla, Laura Y.es_ES
AutorVela, Leonel
AutorBustamante, Alejandraes_ES
AutorRamírez‐Pfeiffer, Carloses_ES
AutorTapia, Beatriz
AutorVela, Leoneles_ES
AutorTapia, Beatrizes_ES
AutorLópez-Alvarenga, Juan Carlos
AutorLópez-Alvarenga, Juan Carloses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
Rango de páginas102873-102873es_ES
URL relacionadahttps://doi.org/10.1016/j.arcmed.2023.102873
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen54es_ES

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