Cadmium exposure negatively affects the microarchitecture of trabecular bone and decreases the density of a subset of sympathetic nerve fibers innervating the developing rat femur

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:39Z
Fecha de publicación2021-01-01
ResumenCadmium (Cd) is toxic to the skeletal system resulting in bone loss and pain. We aimed at determining the effect of chronic Cd exposure on bone density and microarchitecture along with changes in the density of a subset of sensory and sympathetic nerve fibers innervating the developing rat femur. Newborn male Wistar rats were injected daily for 49 days with CdCl2 (1 mg/kg i.p.) or saline solution (control group). At the day of sacrifice, levels of Cd in the right femur, liver and kidney were determined by atomic absorption spectrophotometry. Additionally, microCT followed by immunohistochemical analyses were performed in the left femur. Results showed Cd accumulation in trabecular bone neared levels seen in liver and kidney. Cd concentration in cortical bone was significantly lower versus trabecular bone. MicroCT analysis revealed that Cd-exposed rats had a significant decrease in trabecular bone parameters at the distal femoral metaphysis; however, most of the cortical bone parameters were not significantly affected. Cd-exposed rats showed a significant loss of TH+ sympathetic nerve fibers, but not of CGRP(+) sensory nerve fibers, at the level of bone marrow of the femoral diaphysis as compared to control rats. This study shows that Cd negatively affects bone density and microarchitecture of trabecular bone and decreases the density of sympathetic nerve fibers innervating rat femur. Future studies are warranted to determine the toxigenic mechanisms of Cd on sympathetic nerves and how sympathetic denervation influences bone loss in animals exposed to Cd.es_ES
Doihttps://doi.org/10.1007/s10534-020-00265-xes_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2626
Idiomaenes_ES
EditorialSpringer Science+Business Mediaes_ES
RelaciónBioMetalses_ES
URL relacionadohttps://doi.org/10.1007/s10534-020-00265-xes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteBioMetals
Palabra claveFemures_ES
Palabra claveEndocrinologyes_ES
Palabra claveInternal medicinees_ES
Palabra claveChemistryes_ES
Palabra claveAnatomyes_ES
Palabra claveBone minerales_ES
Palabra claveFemoral neckes_ES
Palabra claveMedicinees_ES
Palabra claveOsteoporosises_ES
Palabra claveSurgeryes_ES
ClasificaciónHeavy Metal Exposure and Toxicityes_ES
TítuloCadmium exposure negatively affects the microarchitecture of trabecular bone and decreases the density of a subset of sympathetic nerve fibers innervating the developing rat femures_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGraniel-Amador, Mayra A.
AutorTorres-Rodríguez, Héctor Fabián
AutorJiménez‐Andrade, Juan Miguel
AutorGraniel-Amador, Mayra A.es_ES
AutorHernández-Rodríguez, Joel
AutorTorres-Rodríguez, Héctor Fabiánes_ES
AutorJiménez‐Andrade, Juan Migueles_ES
AutorArteaga‐Silva, Marcela
AutorHernández-Rodríguez, Joeles_ES
AutorArteaga‐Silva, Marcelaes_ES
AutorMontes, Sergio
AutorMontes, Sergioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas87-96es_ES
URL relacionadahttps://doi.org/10.1007/s10534-020-00265-x
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen34es_ES

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