ASSOCIATION OF THE MTHFR 677C\>T POLYMORPHISM WITH OBESITY AND BIOCHEMICAL VARIABLES IN A YOUNG POPULATION OF MEXICO

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:26Z
Fecha de publicación2019-01-01
ResumenBackground: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship of the MTHFR 677C>T polymorphism with obesity and biochemical variables in young individuals of Mexico. Methods: A total of 316 young individuals were included in the study, 172 with normal weight (NW) and 144 with overweight/obesity. Body mass index (BMI) was classified as NW, overweight, and obesity. Also, waist circumference was measured. Moreover, glucose, total cholesterol, and triglycerides were determined. Genotyping for MTHFR 677C> T polymorphism was performed by the PCR-RFLP method. Results: There was no difference in the distribution of the MTHFR 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW. However, an analysis stratified by gender showed a significant protector effect of the TT genotype against obesity in males and elevated waist circumference in females. Also, overweight/obese individuals with TT genotype had less risk of high cholesterol or triglycerides than overweight/obese subjects with the other genotypes. Conclusions: These results suggest that the MTHFR 677T polymorphism might not be a risk factor for being overweight/obesity. Rather, on the basis of our results, this variant could be a protector effect. However, further large-scale population-based studies are still necessary to clarify the role of the MTHFR 677C>T polymorphism in overweight, obesity, and lipid profile level.es_ES
Doihttps://doi.org/10.2478/jomb-2018-0046es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4268
Idiomaenes_ES
EditorialSCIENDOes_ES
RelaciónJournal of Medical Biochemistryes_ES
URL relacionadohttps://doi.org/10.2478/jomb-2018-0046es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Medical Biochemistry
Palabra claveMTHFRes_ES
Palabra clave677C > Tes_ES
Palabra claveobesityes_ES
Palabra claveoverweightes_ES
Palabra clavebiochemical variableses_ES
TítuloASSOCIATION OF THE MTHFR 677C\>T POLYMORPHISM WITH OBESITY AND BIOCHEMICAL VARIABLES IN A YOUNG POPULATION OF MEXICOes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLeal-Ugarte, Evelia
AutorPeralta-Leal, Valeria
AutorPablo Meza-Espinoza, Juan
AutorDuran-Gonzalez, Jorge
AutorMacias-Gomez, Nelly
AutorBocanegra-Alonso, Anabel
AutorRamon Lara-Ramos, Jose
AutorLeal-Ugarte, Eveliaes_ES
AutorPeralta-Leal, Valeriaes_ES
AutorPablo Meza-Espinoza, Juanes_ES
AutorDuran-Gonzalez, Jorgees_ES
AutorMacias-Gomez, Nellyes_ES
AutorBocanegra-Alonso, Anabeles_ES
AutorRamon Lara-Ramos, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas461-467es_ES
URL relacionadahttps://doi.org/10.2478/jomb-2018-0046
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen38es_ES

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