The Role of GLP1 in Rat Steatotic and Non-Steatotic Liver Transplantation from Cardiocirculatory Death Donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:24Z
Fecha de publicación2019-01-01
ResumenIn liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucagon-like peptide 1 (GLP1) and dipeptidyl peptidase 4 (DPP4), the serine protease that cleaves it, in steatotic and non-steatotic LT from DCDs. Using Zucker rats, liver grafts from DCDs were cold stored and transplanted to recipients. GLP1 was administered to donors. The levels of GLP1 in intestine and of both GLP1 and DDP4 in circulation were unaltered following cardiocirculatory death (CD). In steatotic livers from DCD, increased GLP1 and decreased DPP4 were recorded, and administration of GLP1 caused a rise in hepatic GLP1 and a reduction in DDP4. This protected against inflammation, damage, and proliferation failure. Conversely, low GLP1 and high DDP4 were observed in non-steatotic livers from DCD. The exogenous GLP1 did not modify hepatic DDP4, and the accumulated GLP1 exerted harmful effects, increasing damage, inflammation, and regeneration failure. Herein, we show that there are differences in GLP1/DDP4 regulation depending on the type of liver implanted, suggesting that GLP1 can be used as a novel and effective therapy in steatotic grafts from DCDs but that it is not appropriate for non-steatotic DCDs.es_ES
Doihttps://doi.org/10.3390/cells8121599es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5226
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónCellses_ES
URL relacionadohttps://doi.org/10.3390/cells8121599es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCells
Palabra clavecardiocirculatory deathes_ES
Palabra claveGLP1es_ES
Palabra claveliver transplantationes_ES
Palabra clavesteatotic liver graftses_ES
Palabra claveischemia-reperfusion damagees_ES
TítuloThe Role of GLP1 in Rat Steatotic and Non-Steatotic Liver Transplantation from Cardiocirculatory Death Donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAvalos-de Leon, Cindy G.
AutorJimenez-Castro, Monica B.
AutorEugenia Cornide-Petronio, Maria
AutorCasillas-Ramirez, Arani
AutorPeralta, Carmen
AutorAvalos-de Leon, Cindy G.es_ES
AutorJimenez-Castro, Monica B.es_ES
AutorEugenia Cornide-Petronio, Mariaes_ES
AutorCasillas-Ramirez, Aranies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número12es_ES
URL relacionadahttps://doi.org/10.3390/cells8121599
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen8es_ES

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