Role of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:39Z
Fecha de publicación2016-04-10
ResumenSumatriptan, dihydroergotamine and methysergide inhibit 1\% formalin-induced nociception by activation of peripheral 5-HT1B/1D receptors. This study set out to investigate the pharmacological profile of the antinociception produced by intrathecal and intraplantar administration of ergotamine (a 5-HT1B/1D and 5-HT5A/5B receptor agonist) and valerenic acid (a partial agonist at 5-HT5A receptors). Intraplantar injection of 1\% formalin in the right hind paw resulted in spontaneous flinching behavior of the injected hindpaw of female Wistar rats. Intrathecal ergotamine (15 nmol) or valerenic acid (1 nmol) blocked in a dose dependent manner formalin-induced nociception. The antinociception by intrathecal ergotamine (15 nmol) or valerenic acid (1 nmol) was partly or completely blocked by intrathecal administration of the antagonists: (i) methiothepin (non-selective 5-HT5A/5B; 0.01-0.1 nmol); (ii) SB-699551 (selective 5-HT5A; up to 10 nmol); (iii) anti-5-HT5A antibody; (iv) SB-224289 (selective 5-HT1B; 0.1-1 nmol); or (v) BRL-15572 (selective 5-H-1D; 0.1-1 nmol). Likewise, antinociception by intraplantar ergotamine (15 nmol) and valerenic acid (10 nmol) was: (i) partially blocked by methiothepin (1 nmol), SB-699551 (10 nmol) or SB-224289 (1 nmol); and (ii) abolished by BRL-15572 (1 nmol). The above doses of antagonists (which did not affect per se the formalin-induced nociception) were high enough to completely block their respective receptors. Our results suggest that ergotamine and valerenic acid produce antinociception via 5-HT5A and 5-HT1B/1D receptors located at both spinal and peripheral sites. This provides new evidence for understanding the modulation of nociceptive pathways in inflammatory pain. (C) 2016 Elsevier B.V. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.ejphar.2016.04.009es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2629
Idiomaenes_ES
EditorialElsevier BVes_ES
RelaciónEuropean Journal of Pharmacologyes_ES
URL relacionadohttps://doi.org/10.1016/j.ejphar.2016.04.009es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteEuropean Journal of Pharmacology
Palabra claveMethysergidees_ES
Palabra claveAgonistes_ES
Palabra clavePharmacologyes_ES
Palabra claveChemistryes_ES
Palabra claveErgotaminees_ES
Palabra claveReceptores_ES
Palabra clave5-HT receptores_ES
Palabra claveNociceptiones_ES
Palabra claveSerotonines_ES
Palabra claveInternal medicinees_ES
Palabra claveMedicinees_ES
Palabra claveBiochemistryes_ES
ClasificaciónChemical synthesis and alkaloidses_ES
TítuloRole of 5-HT5A and 5-HT1B/1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin testes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorVidal‐Cantú, Guadalupe C.
AutorJiménez-Hernández, Mildred
AutorRocha-­González, Héctor Isaac
AutorVidal‐Cantú, Guadalupe C.es_ES
AutorVillalón, Carlos M.
AutorJiménez-Hernández, Mildredes_ES
AutorRocha-­González, Héctor Isaaces_ES
AutorGranados‐Soto, Vinicio
AutorVillalón, Carlos M.es_ES
AutorGranados‐Soto, Vinicioes_ES
AutorMuñoz‐Islas, Enriqueta
AutorMuñoz‐Islas, Enriquetaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas109-116es_ES
URL relacionadahttps://doi.org/10.1016/j.ejphar.2016.04.009
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen781es_ES

Files

Collections

Documentación Cientifica