Role of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:06Z
Fecha de publicación2021-01-01
ResumenHerein, we investigate whether: (1) the administration of glucose or a lipid emulsion is useful in liver transplantation (LT) using steatotic (induced genetically or nutritionally) or non-steatotic livers from donors after brain death (DBDs); and (2) any such benefits are due to reductions in intestinal damage and consequently to gut microbiota preservation. In recipients from DBDs, we show increased hepatic damage and failure in the maintenance of ATP, glycogen, phospholipid and growth factor (HGF, IGF1 and VEGFA) levels, compared to recipients from non-DBDs. In recipients of non-steatotic grafts from DBDs, the administration of glucose or lipids did not protect against hepatic damage. This was associated with unchanged ATP, glycogen, phospholipid and growth factor levels. However, the administration of lipids in steatotic grafts from DBDs protected against damage and ATP and glycogen drop and increased phospholipid levels. This was associated with increases in growth factors. In all recipients from DBDs, intestinal inflammation and damage (evaluated by LPS, vascular permeability, mucosal damage, TLR4, TNF, IL1, IL-10, MPO, MDA and edema formation) was not shown. In such cases, potential changes in gut microbiota would not be relevant since neither inflammation nor damage was evidenced in the intestine following LT in any of the groups evaluated. In conclusion, lipid treatment is the preferable nutritional support to protect against hepatic damage in steatotic LT from DBDs; the benefits were independent of alterations in the recipient intestine.es_ES
Doihttps://doi.org/10.3390/nu13082554es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4908
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónNutrientses_ES
URL relacionadohttps://doi.org/10.3390/nu13082554es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteNutrients
Palabra clavebrain deathes_ES
Palabra claveliver transplantationes_ES
Palabra clavesteatotic liver graftses_ES
Palabra claveischemia-reperfusiones_ES
Palabra clavepolysaccharideses_ES
Palabra claveglucosees_ES
Palabra clavelipid emulsiones_ES
Palabra claveintestinal inflammationes_ES
Palabra clavegut microbiotaes_ES
TítuloRole of Dietary Nutritional Treatment on Hepatic and Intestinal Damage in Transplantation with Steatotic and Non-Steatotic Liver Grafts from Brain Dead Donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMico-Carnero, Marc
AutorCasillas-Ramirez, Arani
AutorCaballeria-Casals, Albert
AutorRojano-Alfonso, Carlos
AutorSanchez-Gonzalez, Alfredo
AutorPeralta, Carmen
AutorMico-Carnero, Marces_ES
AutorCasillas-Ramirez, Aranies_ES
AutorCaballeria-Casals, Albertes_ES
AutorRojano-Alfonso, Carloses_ES
AutorSanchez-Gonzalez, Alfredoes_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
URL relacionadahttps://doi.org/10.3390/nu13082554
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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