Mitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusion

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:32Z
Fecha de publicación2019-01-01
ResumenWe analyzed the participation of mitogen-activated protein kinases (MAPKs), namely p38, JNK and ERK 1/2 in steatotic and non-steatotic livers undergoing ischemia-reperfusion (I-R), an unresolved problem in clinical practice. Hepatic steatosis is a major risk factor in liver surgery because these types of liver tolerate poorly to I-R injury. Also, a further increase in the prevalence of steatosis in liver surgery is to be expected. The possible therapies based on MAPK regulation aimed at reducing hepatic I-R injury will be discussed. Moreover, we reviewed the relevance of MAPK in ischemic preconditioning (PC) and evaluated whether MAPK regulators could mimic its benefits. Clinical studies indicated that this surgical strategy could be appropriate for liver surgery in both steatotic and non-steatotic livers undergoing I-R. The data presented herein suggest that further investigations are required to elucidate more extensively the mechanisms by which these kinases work in hepatic I-R. Also, further researchers based in the development of drugs that regulate MAPKs selectively are required before such approaches can be translated into clinical liver surgery.es_ES
Doihttps://doi.org/10.3390/ijms20071785es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5363
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms20071785es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
Palabra claveischemic-reperfusion injuryes_ES
Palabra clavenon-alcoholic fatty liver diseasees_ES
Palabra clavemitogen activated protein kinaseses_ES
Palabra clavesteatosises_ES
TítuloMitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorJimenez-Castro, Monica B.
AutorEugenia Cornide-Petronio, Maria
AutorGracia-Sancho, Jordi
AutorCasillas-Ramirez, Arani
AutorPeralta, Carmen
AutorJimenez-Castro, Monica B.es_ES
AutorEugenia Cornide-Petronio, Mariaes_ES
AutorGracia-Sancho, Jordies_ES
AutorCasillas-Ramirez, Aranies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
URL relacionadahttps://doi.org/10.3390/ijms20071785
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen20es_ES

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