Intra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:38Z
Fecha de publicación2015-01-01
ResumenSeveral studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effect of chronic intra-articular administration of a monoclonal anti-CSF-1R antibody (AFS98) on spontaneous pain, knee edema and functional disabilities in mice with arthritis. Unilateral arthritis was produced by multiple injections of complete Freund's adjuvant (CFA) into the right knee joint of adult male ICR mice. CFA-injected mice were then treated twice weekly from day 10 until day 25 with anti-CSF-1R antibody (3 and 10 mu g/5 mu L per joint), isotype control (rat IgG 10 mu g/5 mu L per joint) or PBS (5 mu l/joint). Knee edema, spontaneous flinching, vertical rearing and horizontal exploratory activity were assessed at different days. Additionally, counts of peripheral leukocytes and body weight were measured to evaluate general health status. Intra-articular treatment with anti-CSF-1R antibody significantly increased horizontal exploratory activity and vertical rearing as well as reduced spontaneous flinching behavior and knee edema as compared to CFA-induced arthritis mice treated with PBS. Treatment with this antibody neither significantly affect mouse body weight nor the number of peripheral leukocytes. These results suggest that blockade of CSF-1R at the initial injury site (joint) could represent a therapeutic alternative for improving the functional disabilities and attenuating pain and inflammation in patients with RA. (C) 2014 Elsevier Ireland Ltd. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.neulet.2014.09.053es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2613
Idiomaenes_ES
EditorialElsevier BVes_ES
RelaciónNeuroscience Letterses_ES
URL relacionadohttps://doi.org/10.1016/j.neulet.2014.09.053es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteNeuroscience Letters
Palabra claveMedicinees_ES
Palabra claveArthritises_ES
Palabra claveInflammationes_ES
Palabra claveEdemaes_ES
Palabra claveRheumatoid arthritises_ES
Palabra claveKnee arthritises_ES
Palabra claveJoint paines_ES
Palabra claveAntibodyes_ES
Palabra claveBlockadees_ES
Palabra claveInternal medicinees_ES
Palabra claveImmunologyes_ES
Palabra claveEndocrinologyes_ES
ClasificaciónRheumatoid Arthritis Research and Therapieses_ES
TítuloIntra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritises_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlvarado-Vázquez, Abigail
AutorMorado-Urbina, Carlos E.
AutorCastañeda‐Corral, Gabriela
AutorAcosta‐González, Rosa Issel
AutorAlvarado-Vázquez, Abigailes_ES
AutorKitaura, Hideki
AutorMorado-Urbina, Carlos E.es_ES
AutorCastañeda‐Corral, Gabrielaes_ES
AutorKimura, Keiji
AutorAcosta‐González, Rosa Isseles_ES
AutorKitaura, Hidekies_ES
AutorTakano‐Yamamoto, Teruko
AutorKimura, Keijies_ES
AutorTakano‐Yamamoto, Terukoes_ES
AutorJiménez‐Andrade, Juan Miguel
AutorJiménez‐Andrade, Juan Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas39-44es_ES
URL relacionadahttps://doi.org/10.1016/j.neulet.2014.09.053
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen584es_ES

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