Cardiovascular risk of metabolic‐dysfunction‐associated steatotic liver disease in Mexican pediatric population

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:41Z
Fecha de publicación2025-01-01
ResumenAbstract Objective This study examines the association between metabolic‐dysfunction‐associated steatotic liver disease (MASLD) and cardiovascular risk, focusing on the predictive value of anthropometric, metabolic, and hepatic markers. Methods A predictive cross‐sectional study was conducted in children aged 5–18 years with overweight, obesity, or metabolic alterations suggestive of hepatic steatosis, with and without MASLD, at a Mexican pediatric endocrine clinic. MASLD was diagnosed via ultrasound, while cardiovascular risk was assessed using carotid intima‐media thickness (CIMT) and metabolic markers. Multiple regression models were developed to evaluate the contribution of vascular (CIMT), anthropometric, metabolic, and hepatic variables to cardiovascular risk. Results Children with MASLD had significantly higher body mass index (BMI) percentiles (97.56 ± 2.93 vs. 68.91 ± 33.89, p  < 0.01), systolic blood pressure (SBP): 113.93 ± 9.38 mmHg versus 101.41 ± 11.45 mmHg, p  < 0.01), and Homeostasis Model Assessment of Insulin Resistance (HOMA‐IR): 7.55 ± 2.23 versus 3.62 ± 1.76, p  < 0.01) compared to controls. CIMT was greater in MASLD patients (0.738 mm vs. 0.56 mm, p  < 0.01), suggesting early vascular remodeling. Model 4, which incorporated CIMT, metabolic markers, and liver enzymes, demonstrated the highest predictive value ( R ² = 0.935, p  < 0.001), reinforcing the multifactorial nature of MASLD‐related cardiovascular risk. Conclusions MASLD is strongly associated with subclinical atherosclerosis and cardiometabolic dysregulation in children. The progressive increase in predictive accuracy across models underscores the importance of a multifactorial approach to cardiovascular risk assessment. Early subclinical cardiovascular findings are detectable in children with MASLD, supporting the rationale for early risk stratification and further research in this population.es_ES
Doihttps://doi.org/10.1002/jpn3.70287es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1683
Idiomaeses_ES
EditorialWileyes_ES
RelaciónJournal of Pediatric Gastroenterology and Nutritiones_ES
URL relacionadohttps://doi.org/10.1002/jpn3.70287es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Pediatric Gastroenterology and Nutrition
TítuloCardiovascular risk of metabolic‐dysfunction‐associated steatotic liver disease in Mexican pediatric populationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGonzález‐Pérez, Brian
AutorSalas‐Flores, Ricardo
AutorLeón‐Escobedo, Raúl De
AutorVázquez‐Nava, Francisco
AutorAltamira‐García, Josefina
AutorPaz‐Ávila, Jaime
AutorGonzález‐Pérez, Brianes_ES
AutorSalas‐Flores, Ricardoes_ES
AutorLeón‐Escobedo, Raúl Dees_ES
AutorVázquez‐Nava, Franciscoes_ES
AutorAltamira‐García, Josefinaes_ES
AutorPaz‐Ávila, Jaimees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas341-349es_ES
URL relacionadahttps://doi.org/10.1002/jpn3.70287
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen82es_ES

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