Identification of candidate genes for reproductive traits in cattle using a functional interaction network approach

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:13Z
Fecha de publicación2020-01-01
ResumenReproduction is a key element in cattle production systems. Systems biology approaches, including those involving gene networks, have been applied to genetic dissection complex phenotypes in cattle. A set of 385 genes associated with reproductive traits in cattle were included in a protein-protein network analysis to identify and prioritize candidate genes related to phenotypic differences in cattle reproduction. Genes belonging to the ubiquitin family - Ubiquitin C (Ubc, Gene ID: 444874) and Ubiquitin B (Ubb, Gene ID: 281370) -had the highest probability of being associated with these traits in cattle. Both proteins were identified as important hubs in a protein-protein interaction network, each having 3,775 interactions of 3,856 possible. Resequencing of the Ubb gene coding region to evaluate the presence of SNPs in a discovery population identified the G/T (rs110366695) transversion. This causes emergence of a stop codon and a protein truncated by 287 aa. The allelic frequency distributions found in two beef cattle breeds highlight the promise of further research into the effects of protein truncation and the potential of these proteins as molecular markers for semen quality.es_ES
Doihttps://doi.org/10.22319/rmcp.v11i3.5279es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5040
Idiomaenes_ES
EditorialINIFAP-CENID PARASITOLOGIA VETERINARIAes_ES
RelaciónRevista Mexicana De Ciencias Pecuariases_ES
URL relacionadohttps://doi.org/10.22319/rmcp.v11i3.5279es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteRevista Mexicana De Ciencias Pecuarias
Palabra claveBovinees_ES
Palabra claveMolecular markerses_ES
Palabra claveSemen qualityes_ES
Palabra claveUbiquitylationes_ES
TítuloIdentification of candidate genes for reproductive traits in cattle using a functional interaction network approaches_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlejandro Paredes-Sanchez, Francisco
AutorTrejo-Martinez, Daniel
AutorVeronica Herrera-Mayorga, Elsa
AutorArellano-Vera, Williams
AutorRodriguez Almeida, Felipe
AutorMaria Sifuentes-Rincon, Ana
AutorAlejandro Paredes-Sanchez, Franciscoes_ES
AutorTrejo-Martinez, Danieles_ES
AutorVeronica Herrera-Mayorga, Elsaes_ES
AutorArellano-Vera, Williamses_ES
AutorRodriguez Almeida, Felipees_ES
AutorMaria Sifuentes-Rincon, Anaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas894-904es_ES
URL relacionadahttps://doi.org/10.22319/rmcp.v11i3.5279
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen11es_ES

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