The role of insulin-like growth factor-I and growth factor-associated signal transduction pathways in estradiol and progesterone facilitation of female reproductive behaviors

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AudienciaPúblico en generales_ES
CoberturaMéxico[ 143]es_ES
Fecha de ingreso2026-10-05T16:34:49Z
Fecha de publicación2006-01-01
ResumenWe are examining the role of insulin-like growth factor-I (IGF-I) and downstream signal transduction pathways associated with growth factors (e.g., mitogen-activated protein kinase, MAPK) in estradiol and progesterone facilitation of female reproductive behavior in rats. Brain IGF-I receptor activity is required for the long-term, priming actions of estradiol on the female reproductive axis. Infusions of an IGF-I receptor antagonist during estradiol priming blocks induction of hypothalamic alpha(1 beta)-adrenergic receptors and luteinizing hormone surges, and attenuates lordosis behavior. Infusion of MAPK and phosphatidylinositol-3-kinase inhibitors inhibitors during estradiol priming completely blocks hormone-facilitated lordosis. Because progestin receptors (PRs) can be phosphorylated and activated by MAPKs, growth factor signaling pathways may also participate in progesterone facilitation of reproductive behaviors. Infusion of a MAPK inhibitor in estradiol-primed rats blocks progestin facilitation and sequential inhibition of lordosis and proceptive behaviors. Interference with MAPK signaling also inhibits behavioral responses to cGNIP and a delta-opioid agonist, both of which can activate MAPK in some cells. Thus MAPK is involved in the facilitation of lordosis and proceptive behaviors, perhaps by phosphorylation of hypothalamic PRs. (c) 2006 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.yfrne.2006.06.001es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6306
IdiomaInglés[20]es_ES
EditorialACADEMIC PRESS INC ELSEVIER SCIENCEes_ES
RelaciónFrontiers in Neuroendocrinologyes_ES
URL relacionadohttps://doi.org/10.1016/j.yfrne.2006.06.001es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteFrontiers in Neuroendocrinology
Palabra claveestradioles_ES
Palabra claveprogesteronees_ES
Palabra claveinsulin-like growth factor-Ies_ES
Palabra claveIGF-Ies_ES
Palabra clavemitogen-activated protein kinasees_ES
Palabra claveMAPKes_ES
Palabra claveluteinizing hormone releasees_ES
Palabra clavelordosises_ES
Palabra clavereproductive behaviores_ES
Palabra claveprogestin receptores_ES
TítuloThe role of insulin-like growth factor-I and growth factor-associated signal transduction pathways in estradiol and progesterone facilitation of female reproductive behaviorses_ES
TipoPonenciaes_ES
ArbitradoHa sido Arbitradoes_ES
AutorEtgen, Anne M.
AutorGonzalez-Flores, Oscar
AutorTodd, Brigitte J.
AutorEtgen, Anne M.es_ES
AutorGonzalez-Flores, Oscares_ES
AutorTodd, Brigitte J.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas363-375es_ES
URL relacionadahttps://doi.org/10.1016/j.yfrne.2006.06.001
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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