New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:54Z
Fecha de publicación2009-01-01
ResumenChagas disease is one of the most important parasitic diseases in Latin America, affecting 16 to 18 million people. Nifurtimox and Benznidazol are drugs that are commonly used in its treatment; however, these drugs produce several adverse reactions and are not effective in the chronic phase of the disease. Therefore, the design, synthesis, and biological evaluation of new compounds with potential activity against Trypanozoma cruzi are of great importance. We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate-dehydrogenase, glyceraldehyde 3-phosphate-dehydrogenase, and hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.es_ES
Doihttps://doi.org/10.2174/092986709788803303es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4738
Idiomaenes_ES
EditorialBENTHAM SCIENCE PUBL LTDes_ES
RelaciónCurrent Medicinal Chemistryes_ES
URL relacionadohttps://doi.org/10.2174/092986709788803303es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteCurrent Medicinal Chemistry
Palabra claveChagas diseasees_ES
Palabra claveTrypanosoma cruzies_ES
Palabra clavetherapeutic targetses_ES
Palabra clavedrug designes_ES
TítuloNew Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectiveses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRivera, Gildardo
AutorBocanegra-Garcia, Virgilio
AutorOrdaz-Pichardo, Cynthia
AutorNogueda-Torres, Benjamin
AutorMonge, Antonio
AutorRivera, Gildardoes_ES
AutorBocanegra-Garcia, Virgilioes_ES
AutorOrdaz-Pichardo, Cynthiaes_ES
AutorNogueda-Torres, Benjamines_ES
AutorMonge, Antonioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número25es_ES
Rango de páginas3286-3293es_ES
URL relacionadahttps://doi.org/10.2174/092986709788803303
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen16es_ES

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