Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:33Z
Fecha de publicación2011-09-26
ResumenThe ultimate goal of vector vaccines is the control of vector infestations while reducing pathogen infection and transmission to protect against the many diseases caused by vector-borne pathogens. Previously (Vaccine 201129:2248-2254), we demonstrated that subolesin vaccination and release of tick larvae after subolesin knockdown by RNA interference (RNAi) were effective for the control of cattle tick, Rhipicephalus (Boophilus) microplus infestations in cattle. In this study, we used the fact that these animals were naturally infected with Anaplasma marginate and Babesia bigemina to evaluate the effect of subolesin vaccination and gene knockdown on tick infection by these cattle tick-transmitted pathogens. Ticks fed on vaccinated cattle had lower subolesin mRNA levels when compared to controls, resembling RNAi results. A. marginate and B. bigemina infection was determined by PCR and decreased by 98\% and 99\%, respectively in ticks fed on vaccinated cattle and by 97\% and 99\%, respectively after subolesin knockdown. These results demonstrated that targeting subolesin expression by vaccination or RNAi results in lower subolesin mRNA and pathogen infection levels, probably due to the effect of subolesin downregulation on tick feeding, gene expression and gut and salivary glands tissue development and function. These results suggested that subolesin vaccines could be used for the dual control of tick infestations and pathogen infection, a result that could be relevant for other vectors and vector-borne pathogens. (C) 2011 Elsevier Ltd. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.vaccine.2011.09.023es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2532
Idiomaenes_ES
EditorialElsevier BVes_ES
RelaciónVaccinees_ES
URL relacionadohttps://doi.org/10.1016/j.vaccine.2011.09.023es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteVaccine
Palabra claveBabesia bigeminaes_ES
Palabra claveBiologyes_ES
Palabra claveVirologyes_ES
Palabra clavePathogenes_ES
Palabra claveVaccinationes_ES
Palabra claveTickes_ES
Palabra claveAnaplasmaes_ES
Palabra claveBabesiosises_ES
Palabra claveGene knockdownes_ES
Palabra claveVector (molecular biology)es_ES
Palabra claveRNA interferencees_ES
Palabra claveAnaplasmosises_ES
ClasificaciónVector-borne infectious diseaseses_ES
TítuloTargeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigeminaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMerino, Octávio
AutorAlmazán, Consuelo
AutorCanales, Mario
AutorVillar, Margarita
AutorMerino, Octávioes_ES
AutorAlmazán, Consueloes_ES
AutorMoreno-Cid, Juan A.
AutorCanales, Marioes_ES
AutorVillar, Margaritaes_ES
AutorGalindo, Ruth C.
AutorMoreno-Cid, Juan A.es_ES
AutorGalindo, Ruth C.es_ES
AutorFuente, José de la
AutorFuente, José de laes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número47es_ES
Rango de páginas8575-8579es_ES
URL relacionadahttps://doi.org/10.1016/j.vaccine.2011.09.023
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen29es_ES

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