Relevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studies

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:39Z
Fecha de publicación2022-03-13
ResumenBiometals are essential during the development of the central nervous system (CNS) since they participate in the organization and regulation of multiple processes related with the proper organization and functioning of brain structures. Neuronal differentiation is a specialized and complex process that occurs actively from embryonic development to the first years of life and is even maintained in specific areas of the mammalian adult brain. In this review, we focus on describing the cellular and molecular mechanisms of trace biometals such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn) on neuronal specialization, comprising from brain uptake to effects on synaptogenesis, axonal outgrowth, myelination, and cellular and neurochemical phenotype determination. We highlight the relevance of biometals in the proper brain functioning by discussing some of the potentially detrimental effects when biometal dyshomeostasis occurs in the brain. Finally, future directions are proposed for exploring the relevance of biometals in brain function using pharmacological, molecular, and analytical approaches.es_ES
Doihttps://doi.org/10.1007/s10534-022-00380-xes_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2627
Idiomaenes_ES
EditorialSpringer Science+Business Mediaes_ES
RelaciónBioMetalses_ES
URL relacionadohttps://doi.org/10.1007/s10534-022-00380-xes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteBioMetals
Palabra claveNeurosciencees_ES
Palabra claveSynaptogenesises_ES
Palabra claveNeurochemicales_ES
Palabra claveCentral nervous systemes_ES
Palabra claveBiologyes_ES
Palabra claveChemistryes_ES
Palabra clavePsychologyes_ES
ClasificaciónTrace Elements in Healthes_ES
TítuloRelevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studieses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorChin-Chan, Miguel
AutorMontes, Sergio
AutorBlanco-Álvarez, Víctor Manuel
AutorChin-Chan, Migueles_ES
AutorAguirre‐Alarcón, Héctor
AutorMontes, Sergioes_ES
AutorBlanco-Álvarez, Víctor Manueles_ES
AutorHernández-Rodríguez, Ignacio
AutorAguirre‐Alarcón, Héctores_ES
AutorHernández-Rodríguez, Ignacioes_ES
AutorBautista, Elizabeth
AutorBautista, Elizabethes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas395-427es_ES
URL relacionadahttps://doi.org/10.1007/s10534-022-00380-x
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen35es_ES

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