Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:25Z
Fecha de publicación2023-01-01
ResumenNorepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous chloride. Inhibition of norepinephrine release by clonidine is correlated with motor deficits after motor cortex injury. The aim of this study was to analyze the role of alpha(2)-adrenergic receptors in the restoration of motor deficits in recovering rats after brain damage. The rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours, 3 days, and 20 days after ferrous chloride-induced cortical injury: saline, clonidine, efaroxan (a selective antagonist of alpha(2)-adrenergic receptors) and clonidine + efaroxan. The sensorimotor score, the immunohistochemical staining for alpha(2A)-adrenergic receptors, and norepinephrine levels were evaluated. Eight hours post-injury, the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased, and these effects were maintained 3 days post-injury. However, 20 days later, clonidine administration diminished norepinephrine levels in the pons compared with the sham group. This effect was accompanied by sensorimotor deficits. These effects were blocked by efaroxan. In conclusion, an increase in alpha(2)-adrenergic receptor levels was observed after injury. Clonidine restores motor deficits in rats recovering from cortical injury, an effect that was prevented by efaroxan. The underlying mechanisms involve the stimulation of hypersensitive alpha(2)-adrenergic receptors and inhibition of norepinephrine activity in the locus coeruleus. The results of this study suggest that alpha(2) receptor agonists might restore deficits or impede rehabilitation in patients with brain injury, and therefore pharmacological therapies need to be prescribed cautiously to these patients.es_ES
Doihttps://doi.org/10.4103/1673-5374.353501es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5244
Idiomaenes_ES
EditorialWOLTERS KLUWER MEDKNOW PUBLICATIONSes_ES
RelaciónNeural Regeneration Researches_ES
URL relacionadohttps://doi.org/10.4103/1673-5374.353501es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteNeural Regeneration Research
Palabra clavealpha2-adrenoceptorses_ES
Palabra claveambulatory behaviores_ES
Palabra claveclonidinees_ES
Palabra clavecortical injuryes_ES
Palabra claveefaroxanes_ES
Palabra clavefunctional recoveryes_ES
Palabra claveimmunohistochemistryes_ES
Palabra clavemotor deficites_ES
Palabra clavenorepinephrinees_ES
Palabra clavesensorimotor scorees_ES
TítuloAlpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injuryes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcia-Diaz, Gabriela
AutorRamos-Languren, Laura E.
AutorParra-Cid, Carmen
AutorLomeli, Joel
AutorMontes, Sergio
AutorRios, Camilo
AutorBueno-Nava, Antonio
AutorValencia-Hernandez, Ignacio
AutorGonzalez-Pina, Rigoberto
AutorGarcia-Diaz, Gabrielaes_ES
AutorRamos-Languren, Laura E.es_ES
AutorParra-Cid, Carmenes_ES
AutorLomeli, Joeles_ES
AutorMontes, Sergioes_ES
AutorRios, Camiloes_ES
AutorBueno-Nava, Antonioes_ES
AutorValencia-Hernandez, Ignacioes_ES
AutorGonzalez-Pina, Rigobertoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas875-880es_ES
URL relacionadahttps://doi.org/10.4103/1673-5374.353501
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen18es_ES

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