Oxidative status in testis and epididymal sperm parameters after acute and chronic stress by cold-water immersion in the adult rat

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:01Z
Fecha de publicación2015-01-01
ResumenStress is associated with detrimental effects on male reproductive function. It is known that stress increases reactive oxygen species (ROS) generation in the male reproductive tract. High ROS levels may be linked to low sperm quality and male infertility. However, it is still not clear if ROS are generated by stress in the testis. The objective of this study was to characterize the role of oxidative stress induced by cold-water immersion stress in the testis of adult male rats and its relation with alterations in cauda epididymal sperm. Adult male rats were exposed to acute stress or chronic stress by cold-water immersion. Rats were sacrificed at 0, 6, 12, and 24 hours immediately following acute stress exposure, and after 20, 40, and 50 days of chronic stress. ROS production increased only at 6 hours post-stress, while the activity and expression of antioxidant enzymes, lipid peroxidation (LPO), and sperm parameters were not modified in the testis. Corticosterone increased immediately after acute stress, whereas testosterone was not modified. After chronic stress, testicular absolute weight decreased; in addition, ROS production and LPO increased at 20, 40, and 50 days. The activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased throughout the duration of chronic stress and the activity of catalase (CAT) decreased at 40 and 50 days, and increased at 20 days. The expression of copper/zinc superoxide dismutase (SOD1) and CAT were not modified, but the expression of phospholipid hydroperoxide glutathione peroxidase (GPx-4) decreased at 20 days. Motility, viability, and sperm count decreased, while abnormal sperm increased with chronic stress. These results suggest that during acute stress there is a redox state regulation in the testis since no deleterious effect was observed. In contrast, equilibrium redox is lost during chronic stress, with low enzyme activity but without modifying their expression. In addition, corticosterone increased while testosterone decreased, this decrease is related to the negative effects seen in sperm.es_ES
Doihttps://doi.org/10.3109/19396368.2015.1008071es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4846
Idiomaenes_ES
EditorialTAYLOR \& FRANCIS INCes_ES
RelaciónSystems Biology in Reproductive Medicinees_ES
URL relacionadohttps://doi.org/10.3109/19396368.2015.1008071es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteSystems Biology in Reproductive Medicine
Palabra claveAntioxidant enzymeses_ES
Palabra clavelipid peroxidationes_ES
Palabra claveoxidative stresses_ES
Palabra claveredox statees_ES
Palabra clavesperm parameterses_ES
Palabra clavestresses_ES
TítuloOxidative status in testis and epididymal sperm parameters after acute and chronic stress by cold-water immersion in the adult rates_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCecilia Garcia-Diaz, Erika
AutorEnrique Gomez-Quiroz, Luis
AutorArenas-Rios, Edith
AutorAragon-Martinez, Andres
AutorAntonio Ibarra-Arias, Juan
AutorRetana-Marquez, Maria del Socorro I.
AutorCecilia Garcia-Diaz, Erikaes_ES
AutorEnrique Gomez-Quiroz, Luises_ES
AutorArenas-Rios, Edithes_ES
AutorAragon-Martinez, Andreses_ES
AutorAntonio Ibarra-Arias, Juanes_ES
AutorRetana-Marquez, Maria del Socorro I.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas150-160es_ES
URL relacionadahttps://doi.org/10.3109/19396368.2015.1008071
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen61es_ES

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