Refractive index based detection of acetaminophen using a simple singlemode–multimode–singlemode fiber-optic sensor

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:56Z
Fecha de publicación2025-01-01
ResumenThis study presents the design, fabrication, and experimental validation of a low-cost optical sensor based on refractive index variation for the detection of acetaminophen (commonly called paracetamol) in liquid solutions. The sensor uses a multimode interference effect under an architecture built with a singlemode–no-core multimode–singlemode fibers (SMF–NC-MMF–SMF or frequently known as SMS). Taking advantage of the self-imaging effect inherent to multimodal interference and the evanescent field interaction with the surrounding media, the sensor exhibits high sensitivity to refractive index changes induced by variations in analyte concentration. Test solutions were prepared from ground commercial tablets containing 85% of active pharmaceutical ingredients. Acetaminophen concentrations in hydroalcoholic solutions, ranging from 17.54 to 128.03 g/kg, were quantified. A progressive shift of the transmission peak toward longer wavelengths, correlated with increasing acetaminophen concentration, was observed when the NC-MMF segment was immersed in each solution. The device demonstrated a spectral sensitivity of 0.024 92 nm/(g/kg), with a linearity (R2 = 0.988), and an estimated limit of detection ∼8.2 g/kg. Additionally, a negative shift attributed to the thermo-optic coefficient of the medium was observed in thermal tests conducted from 20 to 40 °C. However, crystallization effects of acetaminophen are observed above 40 °C, which limits the useful monitoring range. Compared with other methods, the proposed SMS sensor achieves comparable performance through simple construction and without specialized coatings, positioning it as a promising alternative for real-time optical monitoring of pharmaceutical compounds in liquid media.es_ES
Doihttps://doi.org/10.1063/5.0295859es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1878
Idiomaeses_ES
EditorialAIP Publishinges_ES
RelaciónJournal of Applied Physicses_ES
URL relacionadohttps://doi.org/10.1063/5.0295859es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Applied Physics
TítuloRefractive index based detection of acetaminophen using a simple singlemode–multimode–singlemode fiber-optic sensores_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRivera-Peralta, Luis Carlos
AutorZúñiga-Avalos, Yamil Alejandro
AutorDomínguez-Cruz, René Fernando
AutorFuentes-Rubio, Yadira Aracely
AutorAlustiza, Diego
AutorArce, Valeria Beatriz
AutorMineo, Marcos
AutorRivera-Peralta, Luis Carloses_ES
AutorZúñiga-Avalos, Yamil Alejandroes_ES
AutorDomínguez-Cruz, René Fernandoes_ES
AutorFuentes-Rubio, Yadira Aracelyes_ES
AutorAlustiza, Diegoes_ES
AutorArce, Valeria Beatrizes_ES
AutorMineo, Marcoses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número23es_ES
URL relacionadahttps://doi.org/10.1063/5.0295859
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen138es_ES

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