A comparative study of topical natural ergot alkaloids on the intraocular pressure and aqueous humor dynamics in oclular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:48Z
Fecha de publicación2007-01-01
ResumenBackground Although it has been suggested that ergot derivatives may play a role in antiglaucoma therapy, little attention has been paid to the ocular hypotensive action of these drugs. Having previously reported that topical natural ergot alkaloids ergocristine alpha-ergocryptine and ergocornine dose-dependently reduce intraocular pressure in ocular normotensive and alpha-chymotrypsin-induced ocular hypertensive rabbits, the aim of the present work was to compare the effect of ergocristine, alpha-ergocryptine and ergocornine on the intraocular pressure and aqueous humor dynamics in ocular normotensive and alpha-chymotrypsin-induced ocular hypertensive rabbits, in order to further explore the ocular actions of these compounds. Methods Experiments were conducted in albino ocular normotensive and hypertensive rabbits by intracameral injection of alpha-chymotrypsin. Intraocular pressure responses to drug vehicle and seven different doses of topical natural ergot alkaloids were examined, in order to obtain dose-response relationships for comparing the intraocular pressure-lowering effect and potency of these drugs. Tonographies were also performed to ascertain the actions of natural ergot alkaloids on aqueous humor dynamics. Results All natural ergot alkaloids tested reduced intraocular pressure in a dose-related fashion. The ocular hypotensive effect was greater in alpha-chymotrypsin-induced ocular hypertensive rabbits for the three compounds tested. All natural ergot alkaloids tested decreased both tonographic outflow facility and, to a greater extent, aqueous humor inflow in ocular normotensive and in alpha-chymotrypsin-induced ocular hypertensive rabbits. Conclusion Taken together, our data suggest that these compounds decrease both tonographic outflow facility and, to a greater extent, aqueous humor inflow, which explains their final effect in ocular normotensive and in alpha-chymotrypsin-induced ocular hypertensive rabbits. Reductions in aqueous humor inflow observed after topical application of natural ergot alkaloids in alpha-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of aqueous humor, since processes involved in aqueous humor formation may probably be altered after alpha-chymotrypsin injection.es_ES
Doihttps://doi.org/10.1007/s00417-007-0596-3es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4612
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónGraefe's Archive for Clinical and Experimental Ophthalmologyes_ES
URL relacionadohttps://doi.org/10.1007/s00417-007-0596-3es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteGraefe's Archive for Clinical and Experimental Ophthalmology
Palabra claveintraocular pressurees_ES
Palabra claveergot alkaloidses_ES
Palabra claverabbitses_ES
Palabra claveaqueous humor dynamices_ES
TítuloA comparative study of topical natural ergot alkaloids on the intraocular pressure and aqueous humor dynamics in oclular normotensive and α-chymotrypsin-induced ocular hypertensive rabbitses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPuras, Gustavo
AutorSantafe, Juan
AutorSegarra, Jose
AutorGarrido, Manuel
AutorMelena, Jose
AutorPuras, Gustavoes_ES
AutorSantafe, Juanes_ES
AutorSegarra, Josees_ES
AutorGarrido, Manueles_ES
AutorMelena, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número10es_ES
Rango de páginas1559-1567es_ES
URL relacionadahttps://doi.org/10.1007/s00417-007-0596-3
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen245es_ES

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