Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:32Z
Fecha de publicación2022-01-01
ResumenSimple Summary Meconium aspiration syndrome is a pathology that causes hypoxia, acidosis, and neonatal mortality. The mechanisms behind this rely on physiopathology and the interaction of meconium with pulmonary alveolar cells. The inflammatory response, inactivation of surfactant, and processes such as apoptosis or necrosis of alveolar macrophages, epithelial and endothelial cells also participate in this syndrome. In this review, the physiopathology of meconium aspiration syndrome will be discussed in veterinary medicine to understand the inflammatory response and the cellular and biochemical changes at the alveolar level that cause the main outcomes of this pathology. Meconium Aspiration Syndrome is a condition that causes respiratory distress in newborns due to occlusion and airway inflammation, and surfactant inactivation by meconium. This condition has been described in animal species such as canids, sheep, cattle, horses, pigs, and marine mammals. In its pathogenesis, the pulmonary epithelium activates a limited inflammatory response initiated by cytokines causing leukocyte chemotaxis, inhibition of phagocytosis, and pathogen destruction. Likewise, cytokines release participates in the apoptosis processes of pneumocytes due to the interaction of angiotensin with cytokines and the caspase pathway. Due to these reactions, the prevalent signs are lung injury, hypoxia, acidosis, and pneumonia with susceptibility to infection. Given the importance of the pathophysiological mechanism of meconium aspiration syndrome, this review aims to discuss the relevance of the syndrome in veterinary medicine. The inflammatory processes caused by meconium aspiration in animal models will be analyzed, and the cellular apoptosis and biochemical processes of pulmonary surfactant inactivation will be discussed.es_ES
Doihttps://doi.org/10.3390/ani12233310es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5346
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónAnimalses_ES
URL relacionadohttps://doi.org/10.3390/ani12233310es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteAnimals
Palabra clavemeconiumes_ES
Palabra clavepulmonary inflammatory responsees_ES
Palabra claveapoptosises_ES
Palabra claveanimal modelses_ES
Palabra clavesurfactant inactivationes_ES
TítuloMeconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMota-Rojas, Daniel
AutorVillanueva-Garcia, Dina
AutorMota-Reyes, Andrea
AutorOrihuela, Agustin
AutorHernandez-Avalos, Ismael
AutorDominguez-Oliva, Adriana
AutorCasas-Alvarado, Alejandro
AutorFlores-Padilla, Karla
AutorJacome-Romero, Joseline
AutorMartinez-Burnes, Julio
AutorMota-Rojas, Danieles_ES
AutorVillanueva-Garcia, Dinaes_ES
AutorMota-Reyes, Andreaes_ES
AutorOrihuela, Agustines_ES
AutorHernandez-Avalos, Ismaeles_ES
AutorDominguez-Oliva, Adrianaes_ES
AutorCasas-Alvarado, Alejandroes_ES
AutorFlores-Padilla, Karlaes_ES
AutorJacome-Romero, Joselinees_ES
AutorMartinez-Burnes, Julioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número23es_ES
URL relacionadahttps://doi.org/10.3390/ani12233310
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen12es_ES

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