Potential role of systemic thrombolysis in acute submassive intermediate risk pulmonary embolism: Review and future perspectives

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:17Z
Fecha de publicación2016-01-01
ResumenSubmassive (intermediate risk) pulmonary embolism (PE) continues to be a significantly morbid disease process that remains unrecognized, inadequately risk stratified and suboptimally treated. Appropriate early clinical and imaging-based risk stratification represents the cornerstone for adequate therapeutic decision making, particularly for the selection of candidates who may benefit the most from systemic thrombolysis. The relevance of estimating clinical prognostic scores, in combination with imaging data, for accurate assessment of right ventricular function and laboratory biomarkers, indicative of myocardial injury for identification of normotensive patients at intermediate risk for an adverse short-term outcome are emphasized in this review. Recent clinical trials have demonstrated improvement in hemodynamics and mortality with the use of systemic thrombolysis among intermediate risk patients; however, it came at the cost of a significantly increased risk of major bleeding. Catheter-based therapies have garnered considerable clinical interest in recent years; of particular note is the ultrasound accelerated catheter-directed thrombolysis which has emerged as a novel and attractive alternative therapeutic modality with an increasing number of single center studies and ongoing randomized trials. Our review focuses on the major trials and studies involved in submassive PE in the recent literature including the role of thrombolytic therapy. We include major trials with reasonable sample size and extensive review of the potential side effects, such as major bleeding.es_ES
Doihttps://doi.org/10.1177/1753944716630694es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/6065
Idiomaenes_ES
EditorialSAGE Publications Ltdes_ES
RelaciónTherapeutic Advances in Cardiovascular Diseasees_ES
URL relacionadohttps://doi.org/10.1177/1753944716630694es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteTherapeutic Advances in Cardiovascular Disease
Palabra claveclinical outcomeses_ES
Palabra claveright ventricular dysfunctiones_ES
Palabra claverisk stratificationes_ES
Palabra clavesubmassive pulmonary embolismes_ES
Palabra clavesystemic thrombolysises_ES
TítuloPotential role of systemic thrombolysis in acute submassive intermediate risk pulmonary embolism: Review and future perspectiveses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorTeleb, Mohamed
AutorPorres-Aguilar, Mateo
AutorAnaya-Ayala, Javier E.
AutorRodriguez-Castro, Carlos
AutorPorres-Muñoz, Mateo
AutorMukherjee, Debabrata
AutorTeleb, Mohamedes_ES
AutorPorres-Aguilar, Mateoes_ES
AutorAnaya-Ayala, Javier E.es_ES
AutorRodriguez-Castro, Carloses_ES
AutorPorres-Muñoz, Mateoes_ES
AutorMukherjee, Debabrataes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas103-110es_ES
URL relacionadahttps://doi.org/10.1177/1753944716630694
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

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