Antinociceptive and anti-inflammatory effect of a standardized fraction of Oenothera rosea L'Her. ex Aiton and its possible mechanism of action in mice

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:55Z
Fecha de publicación2022-01-01
ResumenObjective: This study was conducted to investigate the antinociceptive and anti-inflammatory effect of ethyl acetate fraction of Oenothera rosea (EAOr) and the mechanism involved, in mice. Materials and Methods: The antinociceptive activity was tested using chemical- and heat-induced nociception models. The anti-inflammatory activity was tested using carrageenan-induced edema and inflammatory cytokines were measured. Results: EAOr reduced the licking time on the second phase of the formalin test (100 and 177 mg/kg). The antinociception of EAOr was prevented by L-NAME (10 mg/kg), 1H-{[}1, 2, 4]-oxadiazolo {[}4, 3-a]-quinoxalin-1-one (ODQ, 0.1 mg/kg), glibenclamide (10 mg/kg) and bicuculline (1 mg/kg), but not by naloxone (2 mg/kg). Also, EAOr decreased licking time in capsaicin induced-nociception. EAOr did not have effect on withdrawal latency in tail-flick test. Carrageenan-induced paw edema was reduced by EAOr, and TNF-alpha and IL-1 beta levels were reduced in mice treated with EAOr by 72.2 and 32.8\%, respectively. Furthermore, EAOr did not present side effects as sedation nor gastric injury. Chemical analysis of this fraction showed the presence of glycosylated quercetin derivatives such as quercetin glucoside and quercetin rhamnoside in a 2.5\% concentration. Conclusion: This study demonstrates antinociceptive and anti-inflammatory effect of an organic fraction of O. rosea and its possible interaction with the NO-cGMP-K+ channels and GABAergic system and thus, it could be considered a therapeutic alternative.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4762
Idiomaenes_ES
EditorialMASHHAD UNIV MED SCIENCESes_ES
RelaciónAvicenna Journal of Phytomedicinees_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteAvicenna Journal of Phytomedicine
Palabra claveOenothera roseaes_ES
Palabra claveNociceptiones_ES
Palabra claveInflammationes_ES
Palabra claveGABAes_ES
Palabra claveNitric oxidees_ES
Palabra clavecGMPes_ES
TítuloAntinociceptive and anti-inflammatory effect of a standardized fraction of Oenothera rosea L'Her. ex Aiton and its possible mechanism of action in micees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorVargas-Ruiz, Rodrigo
AutorEduardo Roa-Coria, Jose
AutorMora-Olivo, Arturo
AutorZamilpa, Alejandro
AutorLucila Herrera-Ruiz, Maribel
AutorIssel Acosta-Gonzalez, Rosa
AutorMariana Montiel-Ruiz, Rosa
AutorVargas-Ruiz, Rodrigoes_ES
AutorEduardo Roa-Coria, Josees_ES
AutorMora-Olivo, Arturoes_ES
AutorZamilpa, Alejandroes_ES
AutorLucila Herrera-Ruiz, Maribeles_ES
AutorIssel Acosta-Gonzalez, Rosaes_ES
AutorMariana Montiel-Ruiz, Rosaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen12es_ES

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