Rapid molecular evolution of Spiroplasma symbionts of Drosophila

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:40Z
Fecha de publicación2021-01-01
ResumenSpiroplasma is a genus of Mollicutes whose members include plant pathogens, insect pathogens and endosymbionts of animals. Spiroplasma phenotypes have been repeatedly observed to be spontaneously lost in Drosophila cultures, and several studies have documented a high genomic turnover in Spiroplasma symbionts and plant pathogens. These observations suggest that Spiroplasma evolves quickly in comparison to other insect symbionts. Here, we systematically assess evolutionary rates and patterns of Spiroplasma poulsonii, a natural symbiont of Drosophila. We analysed genomic evolution of sHy within flies, and sMel within in vitro culture over several years. We observed that S. poulsonii substitution rates are among the highest reported for any bacteria, and around two orders of magnitude higher compared with other inherited arthropod endosymbionts. The absence of mismatch repair loci mutS and mutL is conserved across Spiroplasma, and likely contributes to elevated substitution rates. Further, the closely related strains sMel and sHy (>99.5 \% sequence identity in shared loci) show extensive structural genomic differences, which potentially indicates a higher degree of host adaptation in sHy, a protective symbiont of Drosophila hydei. Finally, comparison across diverse Spiroplasma lineages confirms previous reports of dynamic evolution of toxins, and identifies loci similar to the malekilling toxin Spaid in several Spiroplasma lineages and other endosymbionts. Overall, our results highlight the peculiar nature of Spiroplasma genome evolution, which may explain unusual features of its evolutionary ecology.es_ES
Doihttps://doi.org/10.1099/mgen.0.000503es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5482
Idiomaenes_ES
EditorialMICROBIOLOGY SOCes_ES
RelaciónMicrobial Genomicses_ES
URL relacionadohttps://doi.org/10.1099/mgen.0.000503es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMicrobial Genomics
Palabra clave{*}Correspondencees_ES
Palabra clavemgerth@brookeses_ES
Palabra claveaces_ES
Palabra claveuk DNA repaires_ES
Palabra clavegenome evolutiones_ES
Palabra clavegenome reductiones_ES
Palabra clavemycoplasmaes_ES
Palabra clavesymbiosises_ES
TítuloRapid molecular evolution of Spiroplasma symbionts of Drosophilaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGerth, Michael
AutorMartinez-Montoya, Humberto
AutorRamirez, Paulino
AutorMasson, Florent
AutorGriffin, Joanne S.
AutorAramayo, Rodolfo
AutorSiozios, Stefanos
AutorLemaitre, Bruno
AutorMateos, Mariana
AutorHurst, Gregory D. D.
AutorGerth, Michaeles_ES
AutorMartinez-Montoya, Humbertoes_ES
AutorRamirez, Paulinoes_ES
AutorMasson, Florentes_ES
AutorGriffin, Joanne S.es_ES
AutorAramayo, Rodolfoes_ES
AutorSiozios, Stefanoses_ES
AutorLemaitre, Brunoes_ES
AutorMateos, Marianaes_ES
AutorHurst, Gregory D. D.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
URL relacionadahttps://doi.org/10.1099/mgen.0.000503
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen7es_ES

Files

Collections

Documentación Cientifica