Immunocytochemical detection of progesterone receptor in the female rabbit forebrain

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:08Z
Fecha de publicación2003-01-01
ResumenThere is no information on the neuroanatomical distribution of the progesterone receptor (PR) in the rabbit. Therefore, we mapped the distribution of PR-immunoreactive cells in the forebrain of ovariectomized female rabbits. Vehicle-injected ovariectomized rabbits showed PR-immunoreactive cells only in the infundibular nucleus (IN) and nucleus X (lateral to the ventromedial hypothalamic nucleus). The injection of oestradiol benzoate (EB; 5 mug/day for 5 days) increased the number of PR-immunoreactive cells in the IN and in three nuclei of the preoptic region (periventricular, medial, and principal). Abundant PR were also found in the paraventricular nucleus and nucleus X. Administration of progesterone (10 mg/day) for 3 days to EB-treated rabbits (a treatment that induces digging behaviour for the maternal nest and suppresses sexual receptivity and scent-marking) eliminated PR-immunoreactivity from all brain areas analysed except the IN. Thus, one-third of the number of cells seen in the ovariectomized + EB condition persisted in this region despite progesterone injections. Withdrawal of progesterone (and continuation of EB) for 5 (but not for 2) days (in a schedule similar to the one that induces straw-carrying and hair-pulling for the maternal nest) increased the number of PR-immunoreactive cells in all regions analysed. These results show that restricted regions of the female rabbit forebrain express abundant PR which are either: (i) up-regulated by oestradiol and down-regulated by progesterone; (ii) oestradiol-insensitive and down-regulated by progesterone; or (iii) insensitive to both oestradiol and progesterone.es_ES
Doihttps://doi.org/10.1046/j.1365-2826.2003.01070.xes_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4976
Idiomaenes_ES
EditorialWILEYes_ES
RelaciónJournal of Neuroendocrinologyes_ES
URL relacionadohttps://doi.org/10.1046/j.1365-2826.2003.01070.xes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Neuroendocrinology
Palabra claveprogesterone receptores_ES
Palabra clavematernal behavioures_ES
Palabra clavepreoptic areaes_ES
Palabra clavesexual behavioures_ES
Palabra claveimmunocytochemistryes_ES
TítuloImmunocytochemical detection of progesterone receptor in the female rabbit forebraines_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCaba, M
AutorRovirosa, MJ
AutorBeyer, C
AutorGonzález-Mariscal, G
AutorCaba, Mes_ES
AutorRovirosa, MJes_ES
AutorBeyer, Ces_ES
AutorGonzález-Mariscal, Ges_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
Rango de páginas855-864es_ES
URL relacionadahttps://doi.org/10.1046/j.1365-2826.2003.01070.x
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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