Perinatal asphyxia pathophysiology in pig and human: A review

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:37Z
Fecha de publicación2005-01-01
ResumenIn utero fetuses are evidently exposed to several factors that cause an interruption of the oxygen flow through the umbilical cord causing asphyxia leading to hypoxia and metabolic acidosis. These conditions are important causes of intra-partum and neonatal mortality. The main objective of this review is to provide current information regarding the pathophysiology of asphyxia in piglets around parturition; the physiological mechanisms invoked by affected piglets to compensate perinatal hypoxemia are discussed. This review also addresses some similarities and differences of asphyxia between piglets and other mammals, including human neonates. Metabolic acidosis and hypoxia are sequela to asphyxia and can cause profound health effects in postnatal performance because of an abnormal suckling, a reduced absorption of colostrum and inadequate passive transfer of neonatal immunity. Acidosis also cause hypothermia, increased mortality and reduced survival in neonates. One of the first deleterious effects of intrauterine hypoxia is the expulsion of meconium into the amniotic sac leading to meconium staining of the skin, and in severe cases, meconium aspiration into the lungs. Even though there have been technological changes and improvements in husbandry, piglet mortality due to asphyxia remains a major problem. One potential alternative to reduce neonatal mortality in pigs is the monitoring of fetal stress during birth and the implemention of strategies such as the Apgar score, that is often used in human pediatrics. It is also important to consider the physiological, behavioral and biochemical changes that take place during parturition which subsequently impact the vitality, maturity and development of neonatal pigs. Understanding the pathophysiology of fetal hypoxia should help practitioners and farmers implement more effective delivery techniques aimed at reducing neonatal mortality and improving postnatal performance. (c) 2005 Elsevier B.V All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.anireprosci.2005.01.007es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5412
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónAnimal Reproduction Sciencees_ES
URL relacionadohttps://doi.org/10.1016/j.anireprosci.2005.01.007es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteAnimal Reproduction Science
Palabra clavestillbirthes_ES
Palabra claveperinatal asphyxiaes_ES
Palabra clavepigses_ES
Palabra claveneonatees_ES
Palabra clavemeconium aspirationes_ES
TítuloPerinatal asphyxia pathophysiology in pig and human: A reviewes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlonso-Spilsbury, M
AutorMota-Rojas, D
AutorVillanueva-García, D
AutorMartínez-Burnes, J
AutorOrozco, H
AutorRamírez-Necoechea, R
AutorMayagoitia, AL
AutorTrujillo, ME
AutorAlonso-Spilsbury, Mes_ES
AutorMota-Rojas, Des_ES
AutorVillanueva-García, Des_ES
AutorMartínez-Burnes, Jes_ES
AutorOrozco, Hes_ES
AutorRamírez-Necoechea, Res_ES
AutorMayagoitia, ALes_ES
AutorTrujillo, MEes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1-2es_ES
Rango de páginas1-30es_ES
URL relacionadahttps://doi.org/10.1016/j.anireprosci.2005.01.007
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen90es_ES

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