Facial action units as biomarkers of postoperative pain in ovariohysterectomized bitches treated with cannabidiol and meloxicam

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:15Z
Fecha de publicación2025-01-01
ResumenFacial expression in animals is a suggested method to assess the subtle facial changes associated with pain. This study aimed to evaluate postoperative pain and establish its correlation with facial action units (AUs) in female dogs undergoing elective ovariohysterectomy (OVH) treated with cannabidiol alone or in combination with meloxicam. Sixty healthy female dogs of different breeds, were randomly assigned into four groups according to the treatment. The control group (G(0): n = 15) received a saline solution as placebo; the meloxicam group (G(Mlx): n = 15) received meloxicam at a dose of 0.2 mg kg(-1) IV, followed by 0.1 mg kg(-1) every 24 h, for 48 h during the postoperative period; the cannabidiol group (G(CBD): n = 15) received 2 mg kg(-1) PO every 12 h; and the combination group (G(Mlx/CBD): n = 15) received both treatments. The treatments were administered 30 min before starting the surgery. High-resolution videos were recorded for one minute at baseline and multiple time points up to 48 h post-surgery to quantify facial action units: AU101, AU143 + 145, AU12, ear position, facial muscle tension, orbital tightening, and lip tension. Data was analyzed with a mixed linear model. The frequency of AU143 + 145, AU12, ear position, tension of the facial muscles, orbital tightening, and tension of the lips significantly increased at 30 min, 1 h, 2 h, and 3 h post-surgery (p = 0.0001) in the control group. Thus, facial expressions associated with acute pain in dogs were characterized by AUs such as blink (AU143 + 145), lip corner puller (AU12), ear position, head position, tension of the facial muscles, orbital tightening, and tension of the lips, which maintained a positive moderate correlation with UMPS scores, this association indicates that these facial changes are signs of acute pain in dogs.es_ES
Doihttps://doi.org/10.1016/j.rvsc.2025.105734es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5101
Idiomaenes_ES
EditorialELSEVIER SCI LTDes_ES
RelaciónResearch in Veterinary Sciencees_ES
URL relacionadohttps://doi.org/10.1016/j.rvsc.2025.105734es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteResearch in Veterinary Science
Palabra claveFacial expressionses_ES
Palabra claveAcute paines_ES
Palabra claveDogses_ES
Palabra claveCannabidioles_ES
TítuloFacial action units as biomarkers of postoperative pain in ovariohysterectomized bitches treated with cannabidiol and meloxicames_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCasas-Alvarado, Alejandro
AutorMartinez-Burnes, Julio
AutorMora-Medina, Patricia
AutorHernandez-Avalos, Ismael
AutorMiranda-Cortes, Agatha
AutorDominguez-Oliva, Adriana
AutorMota-Rojas, Daniel
AutorCasas-Alvarado, Alejandroes_ES
AutorMartinez-Burnes, Julioes_ES
AutorMora-Medina, Patriciaes_ES
AutorHernandez-Avalos, Ismaeles_ES
AutorMiranda-Cortes, Agathaes_ES
AutorDominguez-Oliva, Adrianaes_ES
AutorMota-Rojas, Danieles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.1016/j.rvsc.2025.105734
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen193es_ES

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