Involvement of D1 and D2 dopamine receptor in the retrieval processes in latent inhibition

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:32Z
Fecha de publicación2015-01-01
ResumenContemporary theories propose that latent inhibition (LI) is due to a process of interference with the context playing a key role as recovery cue. Physiological studies have demonstrated that LI is a process dependent on striatal dopamine. D2 dopamine receptors have been specifically associated with its expression, while D1 receptor has shown a limited function. However, to evaluate the role of dopamine receptors in LI, it is necessary to analyse their activity during recovery phase, where the mechanisms involved in interference processes are performed. The experiments studied the involvement of the dopaminergic system in the retrieval process of LI. We analysed the effect of the systemic administration of dopaminergic D1 (SCH-23390) and D2 (sulpiride) antagonist during the test phase on LI and on its contextual specificity. Animals were pre-exposed to saccharin solution and conditioned with a LiCl administration in conditioning phase. Dopaminergic antagonist drugs were administered during the test phase. Experiment 2 used the same context in all the phases. Experiment 3 used a new context during conditioning and test phase. The D2 antagonist increased the LI effect and, in turn, diminished the normally suppressant effect of the context shift on LI. The opposite effect was observed under the D1 antagonist administration. This drug disrupted LI and enhanced the effect that the context shift had on this cognitive process. D2 receptor had a relevant role on retrieval processes of pre-exposure learning, while D1 receptor was related with the contextual control of conditioning.es_ES
Doihttps://doi.org/10.1007/s00213-015-4063-2es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4356
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónPsychopharmacologyes_ES
URL relacionadohttps://doi.org/10.1007/s00213-015-4063-2es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuentePsychopharmacology
Palabra claveLatent inhibitiones_ES
Palabra claveDopamine receptorses_ES
Palabra claveRetrievales_ES
Palabra claveSCH-23390es_ES
Palabra claveSulpiridees_ES
TítuloInvolvement of D1 and D2 dopamine receptor in the retrieval processes in latent inhibitiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorDiaz, E.
AutorMedellin, J.
AutorSanchez, N.
AutorVargas, J. P.
AutorLopez, J. C.
AutorDiaz, E.es_ES
AutorMedellin, J.es_ES
AutorSanchez, N.es_ES
AutorVargas, J. P.es_ES
AutorLopez, J. C.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número23es_ES
Rango de páginas4337-4346es_ES
URL relacionadahttps://doi.org/10.1007/s00213-015-4063-2
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen232es_ES

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