Esters of Quinoxaline 1, 4-Di-N-oxide with Cytotoxic Activity on Tumor Cell Lines Based on NCI-60 Panel

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:18Z
Fecha de publicación2017-01-01
ResumenQuinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1,4-di-N-oxide derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1. 4-di-N-oxide substitutes at 7-position with esters group were synthetized and characterized by infrared (IR), proton nuclear magnetic resonance (H-1-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for antitumor activities using the NCI-60 human tumor cell lines screen. Results showed that E7, P3 and E6 were the most active compounds against the cell lines tested. Substitutions at 7-position with esters group not necessarily affect the biological activity, but the nature of the esters group could exert an influence on the selectivity. Additionally, substitutions at 2-position influenced the cytotoxic activity of the compounds.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5111
Idiomaenes_ES
EditorialSHAHEED BEHESHTI UNIV, SCH PHARMACYes_ES
RelaciónIranian Journal of Pharmaceutical Researches_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteIranian Journal of Pharmaceutical Research
Palabra claveAntitumores_ES
Palabra claveCanceres_ES
Palabra claveDrugses_ES
Palabra claveEsterses_ES
Palabra claveQuinoxaline 1es_ES
Palabra clave4-di-N-oxidees_ES
TítuloEsters of Quinoxaline 1, 4-Di-N-oxide with Cytotoxic Activity on Tumor Cell Lines Based on NCI-60 Paneles_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRivera, Gildardo
AutorShah, Syed Shoaib Ahmad
AutorArrieta-Baez, Daniel
AutorPalos, Isidro
AutorMongue, Antonio
AutorSanchez-Torres, Luvia Enid
AutorRivera, Gildardoes_ES
AutorShah, Syed Shoaib Ahmades_ES
AutorArrieta-Baez, Danieles_ES
AutorPalos, Isidroes_ES
AutorMongue, Antonioes_ES
AutorSanchez-Torres, Luvia Enides_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas953-965es_ES
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen16es_ES

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