Neuroprotection of medial septal cholinergic neurons by memantine after intralateral septal injection of Aβ1–40

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:06Z
Fecha de publicación2015-04-25
ResumenAlzheimer's disease (AD) is a progressive disorder of the brain that leads to memory loss, dementia, and death. Several lines of evidence suggest that the accumulation of amyloid-β (Aβ) peptides may trigger the dysfunction and degeneration observed in the AD brain. The basal forebrain, including the septal region, which regulates the excitability of the hippocampus and neocortex, is affected early in AD because its neurons are vulnerable to Aβ peptides. In addition, connections between lateral and medial septal regions (medial septum and diagonal band of Broca) have been demonstrated in previous studies. To demonstrate the involvement of excitotoxicity in Aβ-induced septal damage, we compared rats injected with Aβ1-40 into the lateral septal region structure with rats treated with memantine (a noncompetitive NMDA receptor antagonist), before, during, and after Aβ1-40 injection. Medial septal cholinergic neurons were immunochemically identified and their numbers were estimated using Image J cell count. Our results show that Aβ1-40-treated animals have a significantly low number of medial septum and diagonal band of Broca cholinergic neurons compared with the Aβ/memantine-treated group.es_ES
Doihttps://doi.org/10.1097/wnr.0000000000000364es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2803
Idiomaenes_ES
EditorialLippincott Williams & Wilkinses_ES
RelaciónNeuroreportes_ES
URL relacionadohttps://doi.org/10.1097/wnr.0000000000000364es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteNeuroreport
Palabra claveDiagonal band of Brocaes_ES
Palabra claveMemantinees_ES
Palabra claveNeocortexes_ES
Palabra claveCholinergic neurones_ES
Palabra claveCholinergices_ES
Palabra claveBasal forebraines_ES
Palabra claveNeuroprotectiones_ES
Palabra claveNMDA receptores_ES
Palabra claveHippocampuses_ES
Palabra claveNeurosciencees_ES
Palabra claveSeptal nucleies_ES
Palabra claveHippocampal formationes_ES
ClasificaciónAlzheimer's disease research and treatmentses_ES
TítuloNeuroprotection of medial septal cholinergic neurons by memantine after intralateral septal injection of Aβ1–40es_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCastañeda, María Teresita
AutorLopez, Erick D.
AutorTouhami, Ahmed
AutorTovar, Ramiro
AutorOrtega, Miriam R.
AutorRodríguez, José María Ros
AutorCastañeda, María Teresitaes_ES
AutorLopez, Erick D.es_ES
AutorTouhami, Ahmedes_ES
AutorTovar, Ramiroes_ES
AutorOrtega, Miriam R.es_ES
AutorRodríguez, José María Roses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
Rango de páginas450-454es_ES
URL relacionadahttps://doi.org/10.1097/wnr.0000000000000364
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen26es_ES

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