Association of CAPN10 SNP-19 with Metabolic Traits in Mexican Patients with Type 2 Diabetes

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:07Z
Fecha de publicación2019-01-01
ResumenThe calpain-10 SNP-19 has been associated with diabetes as well as diabetes-related metabolic traits. To analyse the relationship between this polymorphism and anthropometric as well as metabolic traits in Mexican patients with type 2 diabetes, 289 cases and 309 controls were recruited into this study. Body mass index, fasting plasma glucose, glycated haemoglobin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides were assessed. Genotyping was determined by PCR. Apart from HDL-cholesterol, all the metabolic traits were higher in the patients, but the genotype and allele frequencies were similar in both groups. The analysis of the anthropometric and metabolic traits of the patients based on genotype showed differences in waist circumference (p<0.01) and triglycerides (p<0.01); both were higher in subjects with del/del and del/ins genotypes, which suggests an association between CAPN10 SNP-19 and these parameters in Mexican patients with type 2 diabetes. However, additional studies are necessary to clarify the role of this polymorphism in obesity and metabolic traits.es_ES
Doihttps://doi.org/10.31901/24566330.2019/19.01.712es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4945
Idiomaenes_ES
EditorialKAMLA-RAJ ENTERPRISESes_ES
RelaciónInternational Journal of Human Geneticses_ES
URL relacionadohttps://doi.org/10.31901/24566330.2019/19.01.712es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Human Genetics
Palabra claveCAPN10 Genees_ES
Palabra claveSNP-19es_ES
Palabra claveT2Des_ES
Palabra claveObesityes_ES
Palabra claveMetabolic Traitses_ES
TítuloAssociation of CAPN10 SNP-19 with Metabolic Traits in Mexican Patients with Type 2 Diabeteses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMeza-Espinoza, J. P.
AutorLeal-Ugarte, E.
AutorPeralta-Leal, V
AutorFlores-Villarreal, L. E.
AutorPicos-Cardenas, V. J.
AutorSainz-Gonzalez, E.
AutorBocanegra-Alonso, A.
AutorHernandez, J. L.
AutorMeza-Espinoza, J. P.es_ES
AutorLeal-Ugarte, E.es_ES
AutorPeralta-Leal, Ves_ES
AutorFlores-Villarreal, L. E.es_ES
AutorPicos-Cardenas, V. J.es_ES
AutorSainz-Gonzalez, E.es_ES
AutorBocanegra-Alonso, A.es_ES
AutorHernandez, J. L.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas48-53es_ES
URL relacionadahttps://doi.org/10.31901/24566330.2019/19.01.712
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen19es_ES

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