Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:31Z
Fecha de publicación2015-01-01
ResumenSclerostin is a 24-kDa secreted glycoprotein that has been identified as a negative modulator of new bone formation and may play a major role in age-related decline in skeletal function. Although serum levels of sclerostin markedly increase with age, relatively little is known about whether cells in the skeleton change their expression of sclerostin with aging. Using immunohistochemistry and confocal microscopy, we explored sclerostin immunoreactivity (sclerostin-IR) in the femurs of 4-, 9-, and 24-month-old adult C3H/HeJ male mice. In the femur, the only two cell types that expressed detectable levels of sclerostin-IR were bone osteocytes and articular cartilage chondrocytes. At three different sites along the diaphysis of the femur, only a subset of osteocytes expressed sclerostin-IR and the percentage of osteocytes that expressed sclerostin-IR increased from approximately 36% to 48% in 4- vs. 24-month-old mice. In marked contrast, in the same femurs, there were ~40% fewer hypertrophic chondrocytes of articular cartilage that expressed sclerostin-IR when comparing 24- vs. 4-month-old mice. Understanding the mechanism(s) that drive these divergent changes in sclerostin-IR may provide insight into understanding and treating the age-related decline of the skeleton.es_ES
Doihttps://doi.org/10.1369/0022155415626499es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2481
Idiomaeses_ES
EditorialSAGE Publicationses_ES
RelaciónJournal of Histochemistry & Cytochemistryes_ES
URL relacionadohttps://doi.org/10.1369/0022155415626499es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Histochemistry & Cytochemistry
TítuloSclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Micees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorThompson, Michelle L.
AutorJimenez-Andrade, Juan Miguel
AutorMantyh, Patrick W.
AutorThompson, Michelle L.es_ES
AutorJimenez-Andrade, Juan Migueles_ES
AutorMantyh, Patrick W.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas179-189es_ES
URL relacionadahttps://doi.org/10.1369/0022155415626499
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen64es_ES

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