Bonecancer pain: from preclinicalpharmacology toclinical trials

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:19Z
Fecha de publicación2013-01-01
ResumenWorldwide over 12 million people were diagnosed with cancer (excluding non-melanoma skin cancer) and 8 million individuals died from cancer in 2008. Recent data indicate that 75-90\% of patients with advanced stage diseases or metastatic cancer will experience significant cancer pain. Bone cancer pain is common in patients with advanced breast, prostate, and lung cancer as these tumors have a marked affinity to metastasize to bone. Once tumors metastasize to bone, they are a major cause of morbidity and mortality as the tumor induces significant skeletal remodeling, fractures, pain and anemia; all of which reduce the functional status, quality of life and survival of the patient. Currently, the factors that drive cancer pain are poorly understood, however, several recently introduced models of bone cancer pain that mirror the human condition, are providing insight into the mechanisms that drive bone cancer pain and guiding the development of novel therapies to treat the cancer pain. Several of these therapies have recently been approved by the FDA to treat bone cancer pain (bisphosphonates, denosumab) and others are currently being evaluated in human clinical trials (tanezumab). These new mechanism-based therapies are enlarging the repertoire of modalities available to treat bone cancer pain and improving the quality of life and functional status of patients with bone cancer.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5138
Idiomaeses_ES
EditorialACAD NACIONAL MEDICINA MEXICOes_ES
RelaciónGaceta Medica de Mexicoes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteGaceta Medica de Mexico
Palabra claveCanceres_ES
Palabra claveMetastasizees_ES
Palabra claveBonees_ES
Palabra claveAnalgesiaes_ES
TítuloBonecancer pain: from preclinicalpharmacology toclinical trialses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMariana Montiel-Ruiz, Rosa
AutorIssel Acosta-Gonzalez, Rosa
AutorJimenez Andrade, Juan Miguel
AutorMariana Montiel-Ruiz, Rosaes_ES
AutorIssel Acosta-Gonzalez, Rosaes_ES
AutorJimenez Andrade, Juan Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas204-211es_ES
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen149es_ES

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