Association of MHC class II β domain polymorphism in channel catfish (Ictalurus punctatus) with natural infection by Ligictaluridus floridanus

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:43Z
Fecha de publicación2025-01-01
ResumenThe major histocompatibility complex (MHC) class II beta genes are highly polymorphic and trigger the adaptive immune response in fish against parasitic infections. In channel catfish, exon 2 of the HLA (human leukocyte antigens) and H-2 genes encodes the MHC class II beta domain. HLA and H-2 have not been documented in channel catfish populations or associated with parasite infections. We used Ligictaluridus floridanus, a common monogenean ectoparasite, to uncover SNPs in channel catfish. This study uses massive sequencing technology to find single nucleotide polymorphisms (SNPs) in a portion of the MHC class II beta domain of the HLA and H-2 genes. Based on an adjusted parasite load, we ranked fish as resistant (RR) or susceptible (SS) to L. floridanus natural infection. We recovered SNPs from 58 fish, 32 classified as RR and 26 as SS. We found 13 SNPs, resulting in 12 non-synonymous changes (4 in HLA and 8 in H-2) and one synonymous change in the H-2 gene. The GG homozygote genotype for the alternative SNP HLA:1849444(C/G), which changes an aspartate (D) to glutamate (E), was significantly associated with susceptibility to L. floridanus. Our study identified 11 haplotypes in the HLA gene, with only one identical to the previously reported allele Icpu-DAB{*}03 (FKDN). We identified four non-synonymous SNPs in the HLA gene, with a significant association with susceptibility to L. floridanus observed in the genotype GG of SNP HLA:1849444(C/G). In the H-2 gene, the nine SNPs identified were non-significant in any test conducted.es_ES
Doihttps://doi.org/10.1007/s00436-025-08575-0es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4564
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónParasitology Researches_ES
URL relacionadohttps://doi.org/10.1007/s00436-025-08575-0es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteParasitology Research
Palabra claveMHC class II beta domaines_ES
Palabra claveHLAes_ES
Palabra claveH-2es_ES
Palabra claveMonogenean ectoparasiteses_ES
Palabra claveSusceptibilityes_ES
TítuloAssociation of MHC class II β domain polymorphism in channel catfish (Ictalurus punctatus) with natural infection by Ligictaluridus floridanuses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRoldan, Guadalupe Moncerrat Gonzalez
AutorBracamonte, Gaspar Manuel Parra
AutorGonzalez, Flaviano Benavides
AutorAlfaro, Isidro Otoniel Montelongo
AutorDi Carlo Quiroz Velasquez, Jesus
AutorDe La Rosa-Reyna, Xochitl. F.
AutorRoldan, Guadalupe Moncerrat Gonzalezes_ES
AutorBracamonte, Gaspar Manuel Parraes_ES
AutorGonzalez, Flaviano Benavideses_ES
AutorAlfaro, Isidro Otoniel Montelongoes_ES
AutorDi Carlo Quiroz Velasquez, Jesuses_ES
AutorDe La Rosa-Reyna, Xochitl. F.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número10es_ES
URL relacionadahttps://doi.org/10.1007/s00436-025-08575-0
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen124es_ES

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