Pressure Ulcers: Description of a New Model and Use of Mesenchymal Stem Cells for Repair

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:32:12Z
Fecha de publicación2011-01-01
ResumenBackground: Pressure ulcers (PUs) still represent a heavy burden on many patients and nursing institutions. Our understanding of the pathophysiology and development of new treatments are hampered by the scarcity of suitable animal models. Objective: Evaluation of the translational value of an easily accessible mouse model. Methods: PUs were induced by application of magnetic devices on the dorsal skin of mice, which causes localized ischemia. The extent of the lesions and healing rate were quantified. Variations in ischemic exposure time were compared in hairless and normal mice. A detailed histological analysis of regeneration is presented. The influence of streptozotocin-induced diabetes, skin X-irradiation and treatment of the ulcers with human mesenchymal stem cells (MSCs) was investigated using immunodeficient NOD/SCID mice. Results: Ulcers induced by this form of ischemia have many features in common with decubitus ulcers in humans. No difference between hairy and hairless mice was observed in the rate of healing of the PUs. Unexpectedly, healing was not delayed in diabetic mice, but skin X-irradiation prior to ischemia resulted in a doubling of the time to complete closure of the PUs, and delayed repair of the dermis and panniculus carnosus muscle. Intradermal transplantation of human MSCs did not accelerate healing. The grafted MSCs were short-lived and only marginally participated in regeneration by differentiating into tissue-specific cells. Conclusion: The results emphasize the difference in the characteristics of PUs as compared to surgical wounds. This experimental model is recommended for preclinical research on decubitus ulcers because of its mechanistic similarity with clinical PUs and its simplicity.es_ES
Doihttps://doi.org/10.1159/000334628es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/3695
Idiomaenes_ES
EditorialS. Karger AGes_ES
RelaciónDermatologyes_ES
URL relacionadohttps://doi.org/10.1159/000334628es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteDermatology
TítuloPressure Ulcers: Description of a New Model and Use of Mesenchymal Stem Cells for Repaires_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarza-Rodea, Anabel S. de la
AutorKnaän-Shanzer, Shoshan
AutorBekkum, Dirk W. van
AutorGarza-Rodea, Anabel S. de laes_ES
AutorKnaän-Shanzer, Shoshanes_ES
AutorBekkum, Dirk W. vanes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas266-284es_ES
URL relacionadahttps://doi.org/10.1159/000334628
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen223es_ES

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