ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:36Z
Fecha de publicación2019-01-01
ResumenBackground Adiponectin protein and some variations in its gene, ADIPOQ have recently been associated with cancer because they regulate glucose and lipid metabolism as well as anti-apoptotic and anti-inflammatory proteins. Aim The aim of this study was to analyse the relationship between selected biochemical markers, anthropometric indices and ADIPOQ rs2241766 and rs1501299 SNPs in ductal infiltrating breast cancer (DIBC) in a Mexican population. Methods This cross-sectional study included 64 DIBC patients and 167 healthy women. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to identify the genotypes of the rs2241766 (exon 2) and rs1501299 (intron 2) ADIPOQ polymorphisms. Corporal composition and biochemical markers included body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), glucose, cholesterol, triglycerides and high- and low-density lipoprotein cholesterol. Results Patients with DIBC had higher serum glucose, WC and WHR than controls. Intergroup differences in allele and genotype frequencies were found for both polymorphisms (P < 0.05). Patients carrying the rs2241766 TT and TG genotypes had higher values of WC, HC and WHR, but only TG carriers had higher levels of glucose. For the SNP rs1501299, carriers of the GG genotype in the DIBC group had higher values of glucose, WC, HC and WHR than the respective control group. Conclusions These results suggest that WC, HC and WHR are better predictors of DIBC than BMI. The ADIPOQ SNP rs2241766 emerges as a protective factor, whereas rs1501299 is a risk factor for DIBC development in a Mexican population.es_ES
Doihttps://doi.org/10.1371/journal.pone.0214080es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4417
Idiomaenes_ES
EditorialPUBLIC LIBRARY SCIENCEes_ES
RelaciónPLOS ONEes_ES
URL relacionadohttps://doi.org/10.1371/journal.pone.0214080es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuentePLOS ONE
TítuloADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican populationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMargarita Macias-Gomez, Nelly
AutorCarmen Hernandez-Terrones, Maria
AutorAraceli Ramirez-Guerrero, Angelica
AutorLeal-Ugarte, Evelia
AutorGutierrez-Angulo, Melva
AutorPeregrina-Sandoval, Jorge
AutorMargarita Macias-Gomez, Nellyes_ES
AutorCarmen Hernandez-Terrones, Mariaes_ES
AutorAraceli Ramirez-Guerrero, Angelicaes_ES
AutorLeal-Ugarte, Eveliaes_ES
AutorGutierrez-Angulo, Melvaes_ES
AutorPeregrina-Sandoval, Jorgees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
URL relacionadahttps://doi.org/10.1371/journal.pone.0214080
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen14es_ES

Files

Collections

Documentación Cientifica