Vanadium induced ultrastructural changes and apoptosis in male germ cells

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:03Z
Fecha de publicación2005-01-01
ResumenVanadium is a transition metal that is emitted to the atmosphere during combustion of fossil fuels. In the environment, vanadium occurs in the (V) oxidized form. but in the body it is found exclusively in the (IV) oxidized form. Vanadium tetraoxide is an inorganic chemical species in the (IV) oxidized form that has been shown to induce toxic effects in vitro and in vivo. The reproductive toxicity of vanadium in males was studied through monitoring germ cell apoptosis during spermatogenesis. We analyzed ultrastructural damage, and testosterone and progesterone concentrations following vanadium tetraoxide administered to male mice for 60 days. Spermatogenesis stages I-III and X-XII frequently showed apoptotic germ cells in control and treated animals; vanadium tetraoxide treatment induced an increase in the number of Germ cell apoptosis in stages I-III and XII at 9.4 and 18.8 mg/kg, respectively. Although spermatogenesis is regulated by testosterone, in our study this hormone level was not modified by vanadium administration; thus, germ cell death was not related with testosterone concentration. At the ultrastructural level. we observed inclusion structures that varied as to location and content in the Sertoli and germ cells. (c) 2005 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.reprotox.2004.11.016es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4896
Idiomaenes_ES
EditorialPERGAMON-ELSEVIER SCIENCE LTDes_ES
RelaciónReproductive Toxicologyes_ES
URL relacionadohttps://doi.org/10.1016/j.reprotox.2004.11.016es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteReproductive Toxicology
Palabra clavemale reproductive toxicologyes_ES
Palabra clavevanadiumes_ES
Palabra clavetesteses_ES
Palabra clavespermatogenesis stageses_ES
Palabra claveseminiferous epithelium ultrastructurees_ES
Palabra clavegerm cell deathes_ES
Palabra clavetestosteronees_ES
Palabra claveprogesteronees_ES
TítuloVanadium induced ultrastructural changes and apoptosis in male germ cellses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAragón, MA
AutorAyala, ME
AutorFortoul, TI
AutorBizarro, R
AutorAltamirano-Lozano, M
AutorAragón, MAes_ES
AutorAyala, MEes_ES
AutorFortoul, TIes_ES
AutorBizarro, Res_ES
AutorAltamirano-Lozano, Mes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas127-134es_ES
URL relacionadahttps://doi.org/10.1016/j.reprotox.2004.11.016
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen20es_ES

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