Monoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflows

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:27Z
Fecha de publicación2020-01-01
ResumenBlood pressure is a highly controlled cardiovascular parameter that normally guarantees an adequate blood supply to all body tissues. This parameter is mainly regulated by peripheral vascular resistance and is maintained by local mediators (i.e., autacoids), and by the nervous and endocrine systems. Regarding the nervous system, blood pressure can be modulated at the central level by regulating the autonomic output. However, at peripheral level, there exists a modulation by activation of prejunctional monoaminergic receptors in autonomic- or sensory-perivascular fibers. These modulatory mechanisms on resistance blood vessels exert an effect on the release of neuroactive substances from the autonomic or sensory fibers that modify blood pressure. Certainly, resistance blood vessels are innervated by perivascular: (i) autonomic sympathetic fibers (producing vasoconstriction mainly by noradrenaline release); and (ii) peptidergic sensory fibers [producing vasodilatation mainly by calcitonin gene-related peptide (CGRP) release]. In the last years, by using pithed rats, several monoaminergic mechanisms for controlling both the sympathetic and sensory perivascular outflows have been elucidated. Additionally, several studies have shown the functions of many monoaminergic auto-receptors and hetero-receptors expressed on perivascular fibers that modulate neurotransmitter release. On this basis, the present review: (i) summarizes the modulation of the peripheral vascular tone by adrenergic, serotoninergic, dopaminergic, and histaminergic receptors on perivascular autonomic (sympathetic) and sensory fibers, and (ii) highlights that these monoaminergic receptors are potential therapeutic targets for the development of novel medications to treat cardiovascular diseases (with some of them explored in clinical trials or already in clinical use).es_ES
Doihttps://doi.org/10.2174/1570159x18666200503223240es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2426
Idiomaeses_ES
EditorialBentham Science Publishers Ltd.es_ES
RelaciónCurrent Neuropharmacologyes_ES
URL relacionadohttps://doi.org/10.2174/1570159x18666200503223240es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCurrent Neuropharmacology
TítuloMonoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflowses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMarichal-Cancino, Bruno A.
AutorGonzález-Hernández, Abimael
AutorMuñoz-Islas, Enriqueta
AutorVillalón, Carlos M.
AutorMarichal-Cancino, Bruno A.es_ES
AutorGonzález-Hernández, Abimaeles_ES
AutorMuñoz-Islas, Enriquetaes_ES
AutorVillalón, Carlos M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
Rango de páginas790-808es_ES
URL relacionadahttps://doi.org/10.2174/1570159x18666200503223240
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen18es_ES

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