The effect of cortisol in rat steatotic and non-steatotic liver transplantation from brain-dead donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:32Z
Fecha de publicación2017-01-01
ResumenIn the present study, we examined the effects of cortisol on steatotic and non-steatotic liver grafts from brain-dead donors and characterized the underlying mechanisms involved. Non-steatotic liver grafts showed reduced cortisol and increased cortisone levels in association with up-regulation of enzymes that inactivate cortisol. Conversely, steatotic liver grafts exhibited increased cortisol and reduced cortisone levels. The enzymes involved in cortisol generation were overexpressed, and those involved in cortisol inactivation or clearance were down-regulated in steatotic liver grafts. Exogenous administration of cortisol negatively affected hepatic damage and survival rate in non-steatotic liver transplantation (LT); however, cortisol treatment up-regulated the phosphoinositide 3-kinase (PI3K)-protein kinase C (PKC) pathway, resulting in protection against the deleterious effects of brain-dead donors on damage and inflammatory response in steatotic LT as well as in increased survival of recipients. The present study highlights the differences in the role of cortisol and hepatic mechanisms that regulate cortisol levels based on the type of liver. Our findings suggest that cortisol treatment is a feasible and highly protective strategy to reduce the adverse effects of brain-dead donor livers in order to ultimately improve liver graft quality in the presence of steatosis, whereas cortisol treatment would not be recommended for non-steatotic liver grafts.es_ES
Doihttps://doi.org/10.1042/cs20160676es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5356
Idiomaenes_ES
EditorialPORTLAND PRESS LTDes_ES
RelaciónClinical Sciencees_ES
URL relacionadohttps://doi.org/10.1042/cs20160676es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteClinical Science
TítuloThe effect of cortisol in rat steatotic and non-steatotic liver transplantation from brain-dead donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorJimenez-Castro, Monica B.
AutorNegrete-Sanchez, Elsa
AutorCasillas-Ramirez, Arani
AutorGulfo, Jose
AutorAlvarez-Mercado, Ana I.
AutorEugenia Cornide-Petronio, Maria
AutorGracia-Sancho, Jordi
AutorRodes, Juan
AutorPeralta, Carmen
AutorJimenez-Castro, Monica B.es_ES
AutorNegrete-Sanchez, Elsaes_ES
AutorCasillas-Ramirez, Aranies_ES
AutorGulfo, Josees_ES
AutorAlvarez-Mercado, Ana I.es_ES
AutorEugenia Cornide-Petronio, Mariaes_ES
AutorGracia-Sancho, Jordies_ES
AutorRodes, Juanes_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
Rango de páginas733-746es_ES
URL relacionadahttps://doi.org/10.1042/cs20160676
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen131es_ES

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