From genetics to genomics in the rational design of new Mycobacterium tuberculosis vaccines

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:14Z
Fecha de publicación2011-01-01
ResumenTuberculosis (TB) is an infectious disease affecting people from all ages all over the world. It is estimated that one third of the world population lives infected with the causal agent: Mycobacterium tuberculosis. Despite availability and systematic administration of BCG vaccine in endemic areas, TB transmission remains elusive to control, partly because BGC efficacy has been shown to have wide variability (0-80\%). Such variability in protection is attributed to factors including: the BCG strain used for immunization, preexisting exposure to environmental saprophytic Mycobacterium species, and host genetic factors. In this context, efforts regarding to re-engineering BCG vaccines with the ability to prevent latent TB reactivation, providing long lasting protection, and devoid from collateral effects in immunosuppressed people are urgent. In this work we review the actual molecular ``gene-by-gene{''} strategies aimed at generating BCG alternatives, and discuss the urgent necessity of high throughput technology methods for a rational design for a new TB vaccine. (C) 2010 Elsevier Espana, S.L. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.eimc.2011.04.004es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5084
Idiomaeses_ES
EditorialEDICIONES DOYMA S Aes_ES
RelaciónEnfermedades Infecciosas y Microbiologia Clinicaes_ES
URL relacionadohttps://doi.org/10.1016/j.eimc.2011.04.004es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteEnfermedades Infecciosas y Microbiologia Clinica
Palabra claveTuberculosises_ES
Palabra claveBCGes_ES
Palabra claveBioinformaticses_ES
Palabra claveDNA vaccinees_ES
TítuloFrom genetics to genomics in the rational design of new Mycobacterium tuberculosis vaccineses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorBocanegra-Garcia, Virgilio
AutorValencia-Delgadillo, Jorge
AutorCruz-Pulido, Wendy
AutorCantu-Ramirez, Ruben
AutorRivera-Sanchez, Gildardo
AutorPrisco Palma-Nicolas, Jose
AutorBocanegra-Garcia, Virgilioes_ES
AutorValencia-Delgadillo, Jorgees_ES
AutorCruz-Pulido, Wendyes_ES
AutorCantu-Ramirez, Rubenes_ES
AutorRivera-Sanchez, Gildardoes_ES
AutorPrisco Palma-Nicolas, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
Rango de páginas609-614es_ES
URL relacionadahttps://doi.org/10.1016/j.eimc.2011.04.004
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen29es_ES

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