Tilianin obtained from Agastache mexicana inhibits monoamine oxidase and modifies depressive behavior in rats

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:31Z
Fecha de publicación2024-01-01
ResumenAbstract Background Agastache mexicana is used in traditional medicine to treat anxiety, insomnia, pain, among others. In a previous study, the methanolic extract exerted anxiolytic and sedative effects, as observed behaviorally, associated with one of its major components, tilianin. Objective To assess the effect produced by the extracts and tilianin obtained from Agastache mexicana on depressive-induced behavior model and on the activity of monoamine oxidases (MAOs). Methods The depression experimental model consisted of the forced swimming test in rats. MAOs activity was evaluated in cortex and hippocampus from the tilianin and Agastache extracts treated rats using specific inhibitors for each isoform. The quantification of monoamines was carried out using an High Performance Liquid Chromatography method. Results An increase in the swimming time was observed in rodents treated with doses of 16 (226.6 ± 5.5 seconds) and 50 mg/kg (237.8 ± 5.7 seconds) of tilianin, methanolic (260.4 ± 3 seconds), and hydroalcoholic extracts (249.6 ± 2.6 seconds) at 100 mg/kg. MAOs activity was significantly decreased in brain tissue from animals treated with 16 and 50 mg/kg of tilianin, methanolic, and hydroalcoholic extracts at 100 mg/kg. Conclusions The tilianin effect on monoamine oxidases inhibition is confirmed, suggesting its potential use in the treatment of certain neurological disorders.es_ES
Doihttps://doi.org/10.1093/jpp/rgae117es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2507
Idiomaeses_ES
EditorialOxford University Press (OUP)es_ES
RelaciónJournal of Pharmacy and Pharmacologyes_ES
URL relacionadohttps://doi.org/10.1093/jpp/rgae117es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Pharmacy and Pharmacology
TítuloTilianin obtained from Agastache mexicana inhibits monoamine oxidase and modifies depressive behavior in ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRodríguez-Wilson, Edgar
AutorEstrada-Soto, Samuel
AutorRubio-Osornio, Moisés
AutorTristán-López, Luis
AutorNavarrete-Vázquez, Gabriel
AutorGutiérrez-Hernández, Abraham
AutorMontes, Sergio
AutorRodríguez-Wilson, Edgares_ES
AutorEstrada-Soto, Samueles_ES
AutorRubio-Osornio, Moiséses_ES
AutorTristán-López, Luises_ES
AutorNavarrete-Vázquez, Gabrieles_ES
AutorGutiérrez-Hernández, Abrahames_ES
AutorMontes, Sergioes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas396-403es_ES
URL relacionadahttps://doi.org/10.1093/jpp/rgae117
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen77es_ES

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