Antimicrobial Activity of Gels Supplemented With Nanoparticles as Intracanal Medication in Endodontics: A Systematic Review and Meta-Analysis of In Vitro, In Vivo, and RCT Studies

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:01Z
Fecha de publicación2025-01-01
ResumenBackground: The compalete eradication of microorganisms within the root canal system remains a challenge in endodontic treatment. Gels supplemented with nanoparticles, particularly silver nanoparticles (AgNPs), have shown promise in enhancing antimicrobial efficacy. This systematic review and meta-analysis aimed to evaluate the antimicrobial activity of these nanoparticle-supplemented gels as intracanal medication in endodontics.Methods: A comprehensive search was conducted in PubMed, Web of Science, and SCOPUS databases up to September 2024 using specific keywords related to nanoparticles, gels, and antimicrobial activity in endodontics. Only studies published in English were included. In vitro, in vivo, and randomized clinical trials (RCTs) comparing nanoparticle gels with conventional antimicrobial agents were selected based on predefined inclusion and exclusion criteria. Data extraction and risk of bias assessment were performed by independent reviewers. A random-effects model was employed for the meta-analysis to estimate the overall antimicrobial effectiveness of the nanoparticle-supplemented gels. Heterogeneity among studies was evaluated using the I2 statistic.Results: Out of 991 identified records, 752 were screened after duplicate removal, and 24 articles underwent full-text review. Six studies met the eligibility criteria and were included in the final analysis, comprising three in vitro studies, one in vivo study, and RCTs. The meta-analysis revealed that gels supplemented with nanoparticles exhibited a statistically significant positive antimicrobial effect in in vitro studies (pooled effect size: 5.96; 95\% CI: {[}0.92, 10.99]). However, high heterogeneity (I2 = 96\%) was observed. In contrast, the meta-analysis of RCTs indicated no significant overall antimicrobial effect (combined effect: 1.04; 95\% CI: {[}-0.06, 2.15]; I2 = 76\%). Funnel plot asymmetry suggested potential publication bias.Conclusions: Gels supplemented with nanoparticles show potential antimicrobial efficacy in vitro, but the evidence from clinical trials is inconsistent. High heterogeneity and potential publication bias indicate the need for more standardized clinical research to accurately assess the effectiveness of nanoparticle-supplemented gels in endodontic treatment.es_ES
Doihttps://doi.org/10.1155/jnt/8412675es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4843
Idiomaenes_ES
EditorialWILEYes_ES
RelaciónJournal of Nanotechnologyes_ES
URL relacionadohttps://doi.org/10.1155/jnt/8412675es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Nanotechnology
Palabra claveantimicrobial activityes_ES
Palabra claveendodonticses_ES
Palabra claveintracanal medicationes_ES
Palabra clavemeta-analysises_ES
Palabra clavenanoparticleses_ES
Palabra clavesystematic reviewes_ES
TítuloAntimicrobial Activity of Gels Supplemented With Nanoparticles as Intracanal Medication in Endodontics: A Systematic Review and Meta-Analysis of In Vitro, In Vivo, and RCT Studieses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcia, Pedro Rosales
AutorLopez, Eva Concepcion Aguirre
AutorRomano, Jose Eduardo Perez
AutorDominguez, Jorge Humberto Luna
AutorMarin, Nuria Patino
AutorZumaran, Alan Martinez
AutorMontero, Idania De Alba
AutorOrozco, Marco Felipe Salas
AutorGarcia, Pedro Rosaleses_ES
AutorLopez, Eva Concepcion Aguirrees_ES
AutorRomano, Jose Eduardo Perezes_ES
AutorDominguez, Jorge Humberto Lunaes_ES
AutorMarin, Nuria Patinoes_ES
AutorZumaran, Alan Martinezes_ES
AutorMontero, Idania De Albaes_ES
AutorOrozco, Marco Felipe Salases_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1155/jnt/8412675
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen2025es_ES

Files

Collections

Documentación Cientifica