Insights into Growth Factors in Liver Carcinogenesis and Regeneration: An Ongoing Debate on Minimizing Cancer Recurrence after Liver Resection

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2021-01-01
ResumenHepatocellular carcinoma has become a leading cause of cancer-associated mortality throughout the world, and is of great concern. Currently used chemotherapeutic drugs in the treatment of hepatocellular carcinoma lead to severe side effects, thus underscoring the need for further research to develop novel and safer therapies. Liver resection in cancer patients is routinely performed. After partial resection, liver regeneration is a perfectly calibrated response apparently sensed by the body's required liver function. This process hinges on the effect of several growth factors, among other molecules. However, dysregulation of growth factor signals also leads to growth signaling autonomy and tumor progression, so control of growth factor expression may prevent tumor progression. This review describes the role of some of the main growth factors whose dysregulation promotes liver tumor progression, and are also key in regenerating the remaining liver following resection. We herein summarize and discuss studies focused on partial hepatectomy and liver carcinogenesis, referring to hepatocyte growth factor, insulin-like growth factor, and epidermal growth factor, as well as their suitability as targets in the treatment of hepatocellular carcinoma. Finally, and given that drugs remain one of the mainstay treatment options in liver carcinogenesis, we have reviewed the current pharmacological approaches approved for clinical use or research targeting these factors.es_ES
Doihttps://doi.org/10.3390/biomedicines9091158es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5425
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónBiomedicineses_ES
URL relacionadohttps://doi.org/10.3390/biomedicines9091158es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBiomedicines
Palabra claveliver canceres_ES
Palabra claveliver resectiones_ES
Palabra clavegrowth factorses_ES
Palabra claveregenerationes_ES
Palabra clavehepatocyte growth factores_ES
Palabra claveinsulin-like growth factor-1es_ES
Palabra claveepidermal growth factores_ES
TítuloInsights into Growth Factors in Liver Carcinogenesis and Regeneration: An Ongoing Debate on Minimizing Cancer Recurrence after Liver Resectiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlvarez-Mercado, I, Ana
AutorCaballeria-Casals, Albert
AutorRojano-Alfonso, Carlos
AutorChavez-Reyes, Jesus
AutorMico-Carnero, Marc
AutorSanchez-Gonzalez, Alfredo
AutorCasillas-Ramirez, Arani
AutorGracia-Sancho, Jordi
AutorPeralta, Carmen
AutorAlvarez-Mercado, I, Anaes_ES
AutorCaballeria-Casals, Albertes_ES
AutorRojano-Alfonso, Carloses_ES
AutorChavez-Reyes, Jesuses_ES
AutorMico-Carnero, Marces_ES
AutorSanchez-Gonzalez, Alfredoes_ES
AutorCasillas-Ramirez, Aranies_ES
AutorGracia-Sancho, Jordies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
URL relacionadahttps://doi.org/10.3390/biomedicines9091158
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

Files

Collections

Documentación Cientifica