The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:14Z
Fecha de publicación2004-01-01
ResumenIntracerebral and intravenous administration of progesterone (P) and its ring A-reduced metabolites induces intense sexual behavior (lordosis and proceptivity) in estrogen-primed rats. The present study tested the hypothesis that the nitric oxide-cGMP-protein kinase G pathway is involved in the facilitation of sexual behavior induced by the intracerebroventricular (icv) administration of P (130 ng) and its ring A-reduced metabolites 5alpha-dihydroprogesterone (5alpha-DHP; 13 ng) and 5alpha,3alpha-pregnanolone (5alpha,3alpha-PgI; 13 ng). In Experiment 1, we tested the relevance of the nitric oxide/cGMP pathway by infusing a nitric oxide synthase inhibitor or a nitric oxide-dependent, soluble guanylyl cyclase inhibitor icv before progestin administration. The lordosis induced by P, 5alpha-DHP and 5alpha,3alpha-PgI was significantly reduced at 2 h after progestin infusion by the previous injection of either a nitric oxide synthase inhibitor or by a soluble guanylyl cyclase inhibitor. Lordosis behavior returned to control values by 4 h. In Experiment 2, icv infusion of the protein kinase G inhibitor KT5823 significantly inhibited the lordosis behavior induced by all three progestins at 2 h. These data support the hypothesis that the nitric oxide/cGMP/protein kinase G pathway is involved in the lordosis induced by P and some of its ring A-reduced metabolites. (C) 2003 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.yhbeh.2003.08.003es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5079
Idiomaenes_ES
EditorialACADEMIC PRESS INC ELSEVIER SCIENCEes_ES
RelaciónHormones and Behaviores_ES
URL relacionadohttps://doi.org/10.1016/j.yhbeh.2003.08.003es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHormones and Behavior
Palabra claveprogesteronees_ES
Palabra claveL-NAMEes_ES
Palabra claveODQes_ES
Palabra claveKT5823es_ES
Palabra clavelordosises_ES
Palabra clavecGMPes_ES
Palabra clavering A reduced progestinses_ES
Palabra claveprotein kinase Ges_ES
Palabra claveguanylyl cyclasees_ES
Palabra clavenitric oxidees_ES
TítuloThe nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metaboliteses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGonzález-Flores, O
AutorEtgen, AM
AutorGonzález-Flores, Oes_ES
AutorEtgen, AMes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas50-57es_ES
URL relacionadahttps://doi.org/10.1016/j.yhbeh.2003.08.003
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen45es_ES

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