MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukaemia in Mexican Population

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:55Z
Fecha de publicación2022-01-01
ResumenThe C677T polymorphism of the MTHFR gene has been frequently associated with acute lymphoblastic leukaemia ( ALL) around the world. Therefore, the objective of this study was to determine whether the MTHFR C677T polymorphism is associated with ALL in Mexican children and adults. A case-control study was conducted on 243 patients with ALL (136 children and 107 adults) and 379 healthy controls. Genotyping of the C677T polymorphism was performed by the polymerase chain reaction-restriction fragment length polymorphism method. The frequency of the T allele was forty-three percent, fifty- two percent, and forty-six percent in children, adults, and controls, respectively. No risk of ALL was found for T allele carriers in children {[}OR= 0.81 (0.52- 1.25), P=0.33], but an increased risk was detected in adults {[}OR=4.98 (2.24-11.10), P<0.001]. The findings in children agree with most of the studies but are discordant with those reported in adults. These differences could be due to ethnicity, genetic background, sampling, and methodology.es_ES
Doihttps://doi.org/10.31901/24566330.2022/22.03.815es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4761
Idiomaenes_ES
EditorialKAMLA-RAJ ENTERPRISESes_ES
RelaciónInternational Journal of Human Geneticses_ES
URL relacionadohttps://doi.org/10.31901/24566330.2022/22.03.815es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Human Genetics
Palabra claveAdultses_ES
Palabra claveChildrenes_ES
Palabra claveDominant Inheritance Modeles_ES
Palabra claveSusceptibilityes_ES
Palabra claveT Allelees_ES
Palabra claveTT Genotypees_ES
TítuloMTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukaemia in Mexican Populationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPablo Meza-Espinoza, Juan
AutorPeralta-Leal, Valeria
AutorDuran-Gonzalez, Jorge
AutorMacias-Gomez, Nelly
AutorBocanegra-Alonso, Anabel
AutorBarros-Nunez, Patricio
AutorLeal-Ugarte, Evelia
AutorPablo Meza-Espinoza, Juanes_ES
AutorPeralta-Leal, Valeriaes_ES
AutorDuran-Gonzalez, Jorgees_ES
AutorMacias-Gomez, Nellyes_ES
AutorBocanegra-Alonso, Anabeles_ES
AutorBarros-Nunez, Patricioes_ES
AutorLeal-Ugarte, Eveliaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas138-145es_ES
URL relacionadahttps://doi.org/10.31901/24566330.2022/22.03.815
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen22es_ES

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