Non-Structural Proteins (Nsp): A Marker for Detection of Human Coronavirus Families

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:26Z
Fecha de publicación2023-01-01
ResumenSARS-CoV-2 was the cause of the global pandemic that caused a total of 14.9 million deaths during the years 2020 and 2021, according to the WHO. The virus presents a mutation rate between 10−5 and 10−3 substitutions per nucleotide site per cell infection (s/n/c). Due to this, studies aimed at knowing the evolution of this virus could help us to foresee (through the future development of new detection strategies and vaccines that prevent the infection of this virus in human hosts) that a pandemic caused by this virus will be generated again. In this research, we performed a functional annotation and identification of changes in Nsp (non-structural proteins) domains in the coronavirus genome. The comparison of the 13 selected coronavirus pangenomes demonstrated a total of 69 protein families and 57 functions associated with the structural domain’s differentials between genomes. A marked evolutionary conservation of non-structural proteins was observed. This allowed us to identify and classify highly pathogenic human coronaviruses into alpha, beta, gamma, and delta groups. The designed Nsp cluster provides insight into the trajectory of SARS-CoV-2, demonstrating that it continues to evolve rapidly. An evolutionary marker allows us to discriminate between phylogenetically divergent groups, viral genotypes, and variants between the alpha and betacoronavirus genera. These types of evolutionary studies provide a window of opportunity to use these Nsp as targets of viral therapies.es_ES
Doihttps://doi.org/10.3390/pathogens12091185es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2395
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónPathogenses_ES
URL relacionadohttps://doi.org/10.3390/pathogens12091185es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuentePathogens
TítuloNon-Structural Proteins (Nsp): A Marker for Detection of Human Coronavirus Familieses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorTamayo-Ordóñez, María Concepción
AutorRosas-García, Ninfa María
AutorAyil-Gutiérrez, Benjamín Abraham
AutorBello-López, Juan Manuel
AutorTamayo-Ordóñez, Francisco Alberto
AutorAnguebes-Franseschi, Francisco
AutorDamas-Damas, Siprian
AutorTamayo-Ordóñez, Yahaira de Jesús
AutorTamayo-Ordóñez, María Concepciónes_ES
AutorRosas-García, Ninfa Maríaes_ES
AutorAyil-Gutiérrez, Benjamín Abrahames_ES
AutorBello-López, Juan Manueles_ES
AutorTamayo-Ordóñez, Francisco Albertoes_ES
AutorAnguebes-Franseschi, Franciscoes_ES
AutorDamas-Damas, Siprianes_ES
AutorTamayo-Ordóñez, Yahaira de Jesúses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
Rango de páginas1185es_ES
URL relacionadahttps://doi.org/10.3390/pathogens12091185
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen12es_ES

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