Variants in the neuropeptide gene NUCB2 as a possible biomarker for colorectal cancer

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:12Z
Fecha de publicación2025-01-01
ResumenColorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Recent evidence suggests a potential role for the neuropeptide nesfatin-1, encoded by the NUCB2 gene, in cancer development. This study aimed to analyze the association between the rs1330 and rs757081 variants of NUCB2 and CRC in a Mexican population. A total of 780 individuals were included in a cross-sectional study: 397 patients with CRC and 383 healthy controls. The CT and TT genotypes of rs1330 were significantly associated with CRC (odds ratio {[}OR] = 0.6127, P = 0.0029; OR = 2.6574, P = 0.000, respectively), as were the CG and GG genotypes of rs707581 (OR = 0.6825, P = 0.019; OR = 2.6975, P = 0.000, respectively). Hardy-Weinberg equilibrium was not met for either variant (P = 0.000). Haplotype analysis indicated that the T/G haplotype conferred increased risk, while C/C had a protective effect. These findings support a potential role for NUCB2 variants as biomarkers for CRC susceptibility in the Mexican population.es_ES
Doihttps://doi.org/10.62347/qpgo8136es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5013
Idiomaenes_ES
EditorialE-CENTURY PUBLISHING CORPes_ES
RelaciónAmerican Journal of Cancer Researches_ES
URL relacionadohttps://doi.org/10.62347/qpgo8136es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteAmerican Journal of Cancer Research
Palabra claveNucleobindin-2es_ES
Palabra clavenesfatin-1es_ES
Palabra clavecolorectal canceres_ES
Palabra claveallelic variantes_ES
Palabra clavesingle nucleotide polymorphismes_ES
TítuloVariants in the neuropeptide gene NUCB2 as a possible biomarker for colorectal canceres_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMacias-Gomez, Nelly Margarita
AutorReyes-Lucia, Elizabeth
AutorRamirez-Guerrero, Angelica Araceli
AutorGonzalez-Villasenor, Christian Octavio
AutorLeal-Ugarte, Evelia
AutorGutierrez-Angulo, Melva
AutorAyala-Madrigal, Maria de la Luz
AutorGallegos-Arreola, Martha Patricia
AutorMacias-Gomez, Nelly Margaritaes_ES
AutorReyes-Lucia, Elizabethes_ES
AutorRamirez-Guerrero, Angelica Aracelies_ES
AutorGonzalez-Villasenor, Christian Octavioes_ES
AutorLeal-Ugarte, Eveliaes_ES
AutorGutierrez-Angulo, Melvaes_ES
AutorAyala-Madrigal, Maria de la Luzes_ES
AutorGallegos-Arreola, Martha Patriciaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
Rango de páginas4001-4009es_ES
URL relacionadahttps://doi.org/10.62347/qpgo8136
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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