Pro-inflammatory cytokine profile is present in the serum of Mexican patients with different stages of diabetic retinopathy secondary to type 2 diabetes

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:09Z
Fecha de publicación2021-01-01
ResumenAim It's been reported that pro-inflammatory cytokines are elevated in patients with diabetic retinopathy (DR); this may contribute to the pathophysiology of the disease. The aim of this study is to measure the concentration of various inflammatory cytokines from the main CD4+ T helper inflammatory responses in blood serum from Mexican patients with DR in different stages using cytometric bead array (CBA) technology and correlate them with the presence and severity of DR in order to find possible DR biomarkers that serve as diagnostic or therapeutic predictors. Methods 64 subjects were included in the study, 16 in the control group, 16 in the type 2 diabetes mellitus no DR (NDR) group, 16 in the non-proliferative DR (NPDR) group and 16 in the proliferative DR (PDR) group. Cytokine concentrations of interleukin (IL) 1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17A, tumour necrosis factor alpha (TNF alpha) and interferon-gamma in serum samples were measured using Human Inflammatory and TH1/TH2/TH17 CBA Kit. Results IL-6, IL-12, IL-17a and TNF alpha were significantly higher in the patients with DR compared with the control group. The PDR group showed a slightly lower concentration of serum cytokines IL-6, IL-12 and IL-17a. TNF alpha showed a higher concentration compared with healthy controls, NDR and NPDR subjects. We also found a positive statistical correlation between the presence and severity of DR with the clinical parameters haemoglobin A1c, body mass index and serum creatinine and the concentration of serum cytokines IL-6 and TNF alpha. Conclusion Our findings suggest that patients with diabetes and DR have a stronger chronic inflammatory profile compared with non-diabetic subjects.es_ES
Doihttps://doi.org/10.1136/bmjophth-2021-000717es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5002
Idiomaenes_ES
EditorialBMJ PUBLISHING GROUPes_ES
RelaciónBMJ Open Ophthalmologyes_ES
URL relacionadohttps://doi.org/10.1136/bmjophth-2021-000717es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBMJ Open Ophthalmology
TítuloPro-inflammatory cytokine profile is present in the serum of Mexican patients with different stages of diabetic retinopathy secondary to type 2 diabeteses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorUriel Quevedo-Martinez, Jonathan
AutorGarfias, Yonathan
AutorJimenez, Joanna
AutorGarcia, Osvaldo
AutorVenegas, Diana
AutorBautista de Lucio, Victor Manuel
AutorUriel Quevedo-Martinez, Jonathanes_ES
AutorGarfias, Yonathanes_ES
AutorJimenez, Joannaes_ES
AutorGarcia, Osvaldoes_ES
AutorVenegas, Dianaes_ES
AutorBautista de Lucio, Victor Manueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1136/bmjophth-2021-000717
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen6es_ES

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