Ultrastructural changes in the lungs of neonatal rats intratracheally inoculated with meconium

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:01Z
Fecha de publicación2003-01-01
ResumenMeconium aspiration syndrome has been for many years an important cause of neonatal respiratory distress in newborn babies and sporadically reported in animals. This investigation was designed to study the ultrastructural and morphometric changes in the lungs of neonatal rats following the intratracheal inoculation of meconium. Seven-day-old Fischer-344 rats (n = 24) were randomly allocated in two groups. One group was intratracheally inoculated with saline solution and the second group received homologous meconium. Neonates were euthanatized at 1, 3 and 7 postinoculation days (PID) and lungs were examined by light and electron microscopy. Saline solution did not induce any ultrastructural changes in the lung. In contrast, meconium induced deciliation, recruitment of neutrophils and pulmonary alveolar macrophages to the bronchoalveolar space, intravascular sequestration of neutrophils and aggregation of platelets at PID 1 and 3. Other ultrastructural changes at PID 1 and 3 included interstitial edema and escape of red cells and fibrin into the alveolar space and interstitium. Interstitial edema and sequestration of neutrophils were responsible for the significant increase in thickness of alveolar septa. At PID 7 there was hyperplasia and enlargement of type II pneumocytes as well as interstitial proliferation of mesenchymal cells with intra-alveolar fibrosis. It was concluded that intratracheal inoculation of meconium in neonatal rats induces acute ultrastructural changes followed by a reparative response.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4851
Idiomaenes_ES
EditorialF HERNANDEZes_ES
RelaciónHistology and Histopathologyes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHistology and Histopathology
Palabra clavelunges_ES
Palabra claveneonatal ratses_ES
Palabra claveultrastructurees_ES
Palabra clavemeconiumes_ES
Palabra claveaspirationes_ES
TítuloUltrastructural changes in the lungs of neonatal rats intratracheally inoculated with meconiumes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMartinez-Burnes, J
AutorLopez, A
AutorWright, GM
AutorIreland, WP
AutorWadowska, DW
AutorDobbin, GV
AutorMartinez-Burnes, Jes_ES
AutorLopez, Aes_ES
AutorWright, GMes_ES
AutorIreland, WPes_ES
AutorWadowska, DWes_ES
AutorDobbin, GVes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas1081-1094es_ES
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen18es_ES

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