Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:42Z
Fecha de publicación2011-01-01
ResumenAcute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms. Such studies have served to highlight difficulties in conducting statistically and methodologically rigorous investigations into acute lymphoblastic leukemia risk. Recent genome-wide association studies of childhood acute lymphoblastic leukemia have provided robust evidence that common variation at four genetic loci confers a modest increase in risk. The accumulated experience to date and relative lack of success of initial efforts to identify novel acute lymphoblastic leukemia predisposition loci emphasize the need for alternative study designs and methods. The International Childhood Acute Lymphoblastic Leukaemia Genetics Consortium includes 12 research groups in Europe, Asia, the Middle East and the Americas engaged in studying the genetics of acute lymphoblastic leukemia. The initial goal of this consortium is to identify and characterize low-penetrance susceptibility variants for acute lymphoblastic leukemia through association-based analyses. Efforts to develop genome-wide association studies of acute lymphoblastic leukemia, in terms of both sample size and single nucleotide polymorphism coverage, and to increase the number of single nucleotide polymorphisms taken forward to large-scale replication should lead to the identification of additional novel risk variants for acute lymphoblastic leukemia. Ethnic differences in the risk of acute lymphoblastic leukemia are well recognized and thus in assessing the interplay between inherited and non-genetic risk factors, analyses using different population cohorts with different incidence rates are likely to be highly informative. Given that the frequency of many acute lymphoblastic leukemia subgroups is small, identifying differential effects will realistically only be possible through multi-center pooled analyses. Here, we review the rationale for identifying genetic risk variants for acute lymphoblastic leukemia and our proposed strategy for establishing the International Childhood Acute Lymphoblastic Leukaemia Genetics Consortium.es_ES
Doihttps://doi.org/10.3324/haematol.2011.040121es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5502
Idiomaenes_ES
EditorialFERRATA STORTI FOUNDATIONes_ES
RelaciónHaematologica-the Hematology Journales_ES
URL relacionadohttps://doi.org/10.3324/haematol.2011.040121es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteHaematologica-the Hematology Journal
Palabra claveacute lymphoblastic leukemiaes_ES
Palabra clavegeneticses_ES
Palabra claveconsortiumes_ES
Palabra claveetiologyes_ES
TítuloRationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemiaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorSherborne, Amy L.
AutorHemminki, Kari
AutorKumar, Rajiv
AutorBartram, Claus R.
AutorStanulla, Martin
AutorSchrappe, Martin
AutorPetridou, Eleni
AutorSemsei, Agnes F.
AutorSzalai, Csaba
AutorSinnett, Daniel
AutorKrajinovic, Maja
AutorHealy, Jasmine
AutorLanciotti, Marina
AutorDufour, Carlo
AutorIndaco, Stefania
AutorEl-Ghouroury, Eman A.
AutorSawangpanich, Ruchchadol
AutorHongeng, Suradej
AutorPakakasama, Samart
AutorGonzalez-Neira, Anna
AutorUgarte, Evelia L.
AutorLeal, Valeria P.
AutorEspinoza, Juan P. M.
AutorKamel, Azza M.
AutorEbid, Gamal T. A.
AutorRadwan, Eman R.
AutorYalin, Serap
AutorYalin, Erdinc
AutorBerkoz, Mehmet
AutorSimpson, Jill
AutorRoman, Eve
AutorLightfoot, Tracy
AutorHosking, Fay J.
AutorVijayakrishnan, Jayaram
AutorGreaves, Mel
AutorHoulston, Richard S.
AutorSherborne, Amy L.es_ES
AutorHemminki, Karies_ES
AutorKumar, Rajives_ES
AutorBartram, Claus R.es_ES
AutorStanulla, Martines_ES
AutorSchrappe, Martines_ES
AutorPetridou, Elenies_ES
AutorSemsei, Agnes F.es_ES
AutorSzalai, Csabaes_ES
AutorSinnett, Danieles_ES
AutorKrajinovic, Majaes_ES
AutorHealy, Jasminees_ES
AutorLanciotti, Marinaes_ES
AutorDufour, Carloes_ES
AutorIndaco, Stefaniaes_ES
AutorEl-Ghouroury, Eman A.es_ES
AutorSawangpanich, Ruchchadoles_ES
AutorHongeng, Suradejes_ES
AutorPakakasama, Samartes_ES
AutorGonzalez-Neira, Annaes_ES
AutorUgarte, Evelia L.es_ES
AutorLeal, Valeria P.es_ES
AutorEspinoza, Juan P. M.es_ES
AutorKamel, Azza M.es_ES
AutorEbid, Gamal T. A.es_ES
AutorRadwan, Eman R.es_ES
AutorYalin, Serapes_ES
AutorYalin, Erdinces_ES
AutorBerkoz, Mehmetes_ES
AutorSimpson, Jilles_ES
AutorRoman, Evees_ES
AutorLightfoot, Tracyes_ES
AutorHosking, Fay J.es_ES
AutorVijayakrishnan, Jayarames_ES
AutorGreaves, Meles_ES
AutorHoulston, Richard S.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
Rango de páginas1049-1054es_ES
URL relacionadahttps://doi.org/10.3324/haematol.2011.040121
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen96es_ES

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