Mecanismos neurobiológicos del dolor de origen no maligno asociado a estructuras óseas

Abstract

Introduction. Despite the high prevalence of musculoskeletal diseases, the neurobiological mechanisms underlying bone-related pain are not fully known. Objective. To summarize the information on neurobiological mechanisms of bone structures-related pain that has been reported in the last two decades. Material and Methods. A scientific search was performed on the PubMed platform in the last 20 years using the keywords pain, bone, skeletal, non-malignant, aging, periosteum, and nerve fibers. Results and Discussion. Significant advances in biochemical, immunohistochemical and imaging techniques have helped to characterize sensory and sympathetic innervation of different natural compartments in healthy tissue. Likewise, several preclinical models of acute and chronic musculoskeletal pain —providing a clearer understanding of the mechanisms underlying bone-related pain— have been established.